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Babu, Kondra Sudhakar
- Design, Synthesis, Structural Elucidation and Antimicrobial Screening of Novel 1, 5-Benzothiazepine Derivatives Derived from Thieno [3, 2-d] Pyrimidine Nucleus
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Authors
Virupakshi Prabhakar
1,
Kondra Sudhakar Babu
2,
L. K. Ravindranath
2,
J. Latha
3,
B. Venkateswarlu
4
Affiliations
1 SVR Engineering College, Jawaharlal Nehru Technological University-Ananthapuramu (JNTU-A), Nandyal, Pin 518502, Kurnool (Dist), A.P., IN
2 Department of Chemistry, Sri Krishnadevaraya University, Ananthapuramu, (A P), IN
3 Department of Environmental Science, Sri Krishnadevaraya University College of Engineering and Technology, S. K. University, Ananthapuramu – 515003 (A.P), IN
4 PBR VITS, Jawaharlal Nehru Technological University (JNTU-A), Kavali, Nellore (Dist), (A.P.), IN
1 SVR Engineering College, Jawaharlal Nehru Technological University-Ananthapuramu (JNTU-A), Nandyal, Pin 518502, Kurnool (Dist), A.P., IN
2 Department of Chemistry, Sri Krishnadevaraya University, Ananthapuramu, (A P), IN
3 Department of Environmental Science, Sri Krishnadevaraya University College of Engineering and Technology, S. K. University, Ananthapuramu – 515003 (A.P), IN
4 PBR VITS, Jawaharlal Nehru Technological University (JNTU-A), Kavali, Nellore (Dist), (A.P.), IN
Source
Asian Journal of Research in Chemistry, Vol 10, No 1 (2017), Pagination: 58-68Abstract
1, 5-Benzo Thiazepine is the Main Seven membered Heterocyclic ring systems reported for their cardiac and Psychotherapeutic activities.1,5 Benzo Thiazepines were highlighted as important Biologically active Scaffolds. In This Article New series of benzo [b] [1, 5]-thiazepine derivatives 6 a-j were synthesized by applying the cyclo condensation of (E)-3-(thieno [3, 2-d] pyrimidin-6-yl)-1-p-Substituted prop-2-en-1-one derivatives 4a-j with 2-amino thio phenol (5) in DMF. The new intermediate Chalcone derivatives 4a-j were obtained from interaction of various P-substituted Acetophenone&Heterocyclic Acetyl derivatives 3(a-j) and thieno[3,2-d]pyrimidine-7-carbaldehyde. The synthesized 1, 5-benzothiazepines 6a-j have been screened for their antimicrobial activity. From anti-bacterial and anti-fungal activity screening results, it has been observed that compounds 6h, 6e, 6i and 6d possess good activity.Keywords
Chalcones, 2-Amino Thio Phenol, Cyclisation, 1, 5-Benzothiazepines, Anti-Microbial Activity, Thieno [3, 2-d] Pyrimidine Core Ring.
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Abstract Views :218 |
PDF Views:6
Authors
Virupakshi Prabhakar
1,
Kondra Sudhakar Babu
2,
L. K. Ravindranath
2,
M. Sahanoor Basha
1,
J. Latha
3
Affiliations
1 SVR Engineering College, Jawaharlal Nehru Technological University-Ananthapuramu (JNTU-A), Nandyal, Pin 518502, Kurnool (Dist), A.P., IN
2 Department of Chemistry, Sri Krishnadevaraya University, Ananthapuramu, (A P), IN
3 Department of Environmental Science, Sri Krishnadevaraya University College of Engineering and Technology, S.K. University, Ananthapuramu – 515003 (A.P), IN
1 SVR Engineering College, Jawaharlal Nehru Technological University-Ananthapuramu (JNTU-A), Nandyal, Pin 518502, Kurnool (Dist), A.P., IN
2 Department of Chemistry, Sri Krishnadevaraya University, Ananthapuramu, (A P), IN
3 Department of Environmental Science, Sri Krishnadevaraya University College of Engineering and Technology, S.K. University, Ananthapuramu – 515003 (A.P), IN