Refine your search
Collections
Co-Authors
Year
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Bhanushali, M. D.
- Synthesis, Anti-bacterial, Anti-fungal and Anti-inflammatory Activities of some Novel 3, 5-Diaryl-1-Aryl Pyrazoline Derivatives
Abstract Views :260 |
PDF Views:2
Authors
Affiliations
1 Research Scholar, Bhagwant University, Ajmer and Department of Pharmaceutical Chemistry, Maratha Mandal’s College of Pharmacy, Belgaum. 590 016
2 Department of Pharmaceutical Chemistry, KLE University’s, College of Pharmacy, Rajajinagar, Bangalore-40
1 Research Scholar, Bhagwant University, Ajmer and Department of Pharmaceutical Chemistry, Maratha Mandal’s College of Pharmacy, Belgaum. 590 016
2 Department of Pharmaceutical Chemistry, KLE University’s, College of Pharmacy, Rajajinagar, Bangalore-40
Source
Asian Journal of Research in Chemistry, Vol 6, No 7 (2013), Pagination: 618-622Abstract
4-substituted acetanilide on treatment with substituted benzaldehyde affords the corresponding chalcones (C<SUB>13</SUB>-C<SUB>24</SUB>). Further treatment of chalcones with phenylhydrazine undergone cyclocondensation and gave a new series of novel 3, 5-Diaryl-1-aryl-2- pyrazoline (P13-P24). All synthesized compounds were screened for their antibacterial and antifungal activity at 75μg concentration and anti-inflammatory activity at 200mg/ kg body weight. Some of the compounds have shown excellent activityKeywords
Pyrazoline, Antibacterial, Antifungal, Anti-tubercular Activity
References
- Wiley RH. The chemistry of heterocylic chemistry, Pyrazole, Pyrazoline, Pyrazolidine, Indazoles and condensed rings. Behr LC, Fusco R, Jarboe CH. Interscience publishers; John Wiley and Sons; 1967: 3-20.
- Rani M, Yusuf M and Khan SA. Synthesis and in-vitro antibacterial activity of [5-(furan-2-yl)-phenyl]-4, 5- carbothioamide-pyrazolines. Journal of Saudi Chemical society. 16;2012:431-436.
- Kini S and Gandhi AM. Novel 2-pyrazoline derivatives as potential antibacterial and antifungal agents. Indian Journal of Pharmaceutical sciences. 70(1); 2008: 105-108.
- khunt RC. et.al. Synthesis, antitubercular evaluation and 3DQSAR study of N-phenyl-3-(4-fluorophenyl)-4-substituted pyrazole derivatives. Bioorganic and Medicinal Chemistry Letters. 22; 2012: 666–678.
- Amir M, Harishkumar and Khan SA. Synthesis and pharmacological evaluation of pyrazoline derivatives as new antiinflammatory and analgesic agents. Bioorganic and Medicinal Chemistry Letters. 18; 2008: 918–922.
- Malhotra P, Pattan S and Nikalje AP. Microwave assisted synthesis and anti-inflammatory activity of 3, 5-diaryl substituted-2-pyrazoline. International journal of Pharmacy and pharmaceutical sciences. 2(2); 2010:21-26.
- Cui-Yun Li. et. al. Synthesis, biological evaluation and 3DQSAR studies of novel
- , 5-dihydro-1H-pyrazole niacinamide derivatives as BRAF inhibitors. Bioorganic and Medicinal Chemistry. 20(12);. 2012: 3746-3755.
- Sowmya HG and Javali C. Design, Synthesis and Evaluation of some substituted pyrazoline derivatives for their anti-convulsant activity. International Journal of Pharma World Research. 3(2); 2012.
- Palaska E, Aytemir M, Uzbay IT and ERol D. Synthesis and antidepressant activities of some 3, 5-diphenyl-2- pyrazolines. European Journal of Medicinal chemistry. 36; 2001: 539-543.
- Rahaman SA, Ragjendra Prasad Y, Bhuvaneswari K and Phanikumar. Synthesis and anti-histaminic activity of novel pyrazoline derivatives. International Journal of Chem Tech Research. 2(1); 2010: 16-20.
- Hipparagi SM, Bhanushali MD, patil SA and Desai NS. Synthesis and Anti-infective studies of some novel pyrazoline derivatives. Asian J. Research Chem. 5(10); Oct 2012: 1251- 1254.
- Arunkumar S, Ilango K, Manikandan RS and Ramalakshmi N. Synthesis and anti-inflammatory activity of some novel pyrazole derivatives of gallic acid. E-J-Chem. 6(S1):; 2009: S123-S128.
- Anoop Singh and Rana AC. Synthesis and anticonvulsant activity of 1-[(4, 5-dihydro-5-phenyl-3(phenylamino) pyrazol-1-yl)] ethanone derivatives J. Chem. Pharm. Res. 2(1); 2010: 505-511.
- Sahu S K, Banerjee M, Samantray A, Behra C and Azam M A. Synthesis, Analgesic, Anti-inflammatory and antimicrobial activities of some novel pyrazoline derivatives. Trop. J. Pharm. Res. 7(2); 2008: 961-968.
- Barry AL. The Antimicrobial Susceptiblity Test: Principle and Practics, Edited by Illus leu and Febiger (Philadelphia. Pa. USA). 180; BIol. Abstr. 1976; 64: 25783.
- Vogel GH, Drug Discovery and Evaluation- Pharmacological Assays, 2nd ed., New York; Springer Verlag; 2002: 751-71.