Asian Journal of Research in Chemistry

S. M. Sarode ¹, A. R. Bendale ², M. Mittal ¹, M. A. Chaudhri ³, M. K. Kale ³, G. Vidyasagar ⁴, B. Shrivastava ⁵

Affiliations
1 Department of Pharmaceutics, Jaipur National University, Jagatpura, Jaipur- 425201, IN
2 B.N.B.Swaminarayan College of Pharmacy, Vapi, Gujrat, IN
3 K.Y.D.S.C.T’s College of Pharmacy, Sakegaon (M.S.), IN
4 Veerayatan Institute of Pharmacy, Bhuj, Gujrat, IN
5 School of Pharmaceutical Sciences, Jaipur National University, Jaipur, IN

Abstract

An abundance of the anti-inflammatory drugs are available for use in current medicine which have an established use in the treatment of arthritis and other painful conditions, amongst them one of the novel drug is Aceclofenac. Gels are an excellent formulation for several routes of administration such as oral, topical, nasal, vaginal, and rectal. Gel can be clear formulations when all of the particles completely dissolve in the dispersing medium. But this doesn't occur in all gels, and some are therefore turbid. This need has emphasized the importance of developing a topical dosage form of such drugs.

Aceclofenac is novel non steroidal anti-inflammatory drug which have proven its effectiveness in many of painful diseased conditions like osteoarthritis, rheumatoid arthritis, spondylitis etc. Like other NSAIDs it is also associated with adverse effects, majority of them are of gastrointestinal system (dyspepsia, abdominal pain, nausea and diarrhea). Present study was undertaken to develop an effective and stable topical formulations of Aceclofenac gel.

Keywords

TDDS, Aceclofenac.

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R. W. Lohe ¹, P. B. Suruse ¹, M. K. Kale ¹, P. R. Barethiya ², A. V. Kasture ², S. W. Lohe ³

Affiliations
1 Kamla Nehru College of Pharmacy, Butibori, Nagpur-441108 (MS), IN
2 Institute of Pharmaceutical Education and Research, Borgaon (Meghe), Wardha-442001 (MS), IN
3 Anurag College of Pharmacy, Warthi, Bhandara (MS), IN

Abstract

Two simple, accurate, economical and reproducible spectrophotometric methods for simultaneous estimation of Rabeprazole and Diclofenac in combined tablet dosage form have been developed. The first developed method employs formation and solving of simultaneous equation using two wavelengths 294.0 nm and 281.2 nm for formation of simultaneous equation. Second developed method involves graphical absorbance ratio, using two wavelengths. Both of these methods obey Beer’s law in the employed concentration ranges for respective methods. Results of analysis were validated statistically and by recovery studies.

Keywords

Spectrophotometric Estimation, Rabeprazole, and Diclofenac.

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