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Authors
Affiliations
1 Al-Azhar University, Nasr City 11884, Cairo, EG
2 Chemical Laboratory of Medico-Legal Department, Ministry of Justice, Cairo, EG
Source
Asian Journal of Research in Chemistry, Vol 4, No 9 (2011), Pagination: 1388-1392
Abstract
A simple and sensitive extractive spectrophometric method has been described for the assay of Mianserin hydrochloride (M-HCl) either in pure form or in pharmaceutical solid dosage form. The developed method involves formation of colored chloroform extractable ion-association complex of Mianserin hydrochloride (M-HCl) with Picric acid (PA), Chlorophenol red (ClPR), Bromthymol blue (BrTB), Bromcresol purple (BrCP) reagents. The extracted complexes showed absorbance maxima at optimum wavelength using visible spectrophotometer. Beer's law is obeyed in the concentration range of 1-42 μg/mL. Correlation coefficient was found to be ≥ 0.9985. In addition we have determined the molar absorptivity, Sandell sensitivity and the optimum conditions for quantitative analysis of the investigated drugs.
Keywords
Spectrophotometry, Mianserin Hydrochloride, Chloroform, Pharmaceutical Analysis, Ion-Association Complex.
