Asian Journal of Research in Chemistry

Md. Saddam Hossain ¹, C. M. Zakaria ¹, Md. Kudrat-E-Zahan ¹

Affiliations
1 Department of Chemistry, University of Rajshahi, Rajshahi-6205, BD

Abstract

Thiosemicarbazones are Schiff base ligands which have achieved much attention by the scientist over the decades as potential drug agent. Isatin is an endogenous compound isolated in 1988 and reported to possess a wide range of structural and biological activities involving the central nervous system. The versatility and flexibility of Schiff base compounds having, acyl, aroyl and heteroacroyl ligands have additional donor sites >C=O, >C=N-, >C=S etc. have made the Schiff bases to act as good complexing agents that form a variety of complexes with various transition and inner transition metals which also emphasized the attention of many researchers. Azomethine linkage(-CH=N-) of Schiff base play an significant role in medical field with so many pharmacological applications such as antimicrobial, antiviral, anti-tubercularculosis, anti-HIV, anti-diuretic and anticancer activity. The potency of these pharmaceutically useful drugs in treatment of microbial infections and other activities inspired the scientist for the development of some more potent and significant compounds and metal complexes over the years. Schiff base ligands are considered privileged ligands because they are easily prepared by a simple condensation reaction of an aldehyde and primary amines. In this review, the synthesis, biological activities along with application of Schiff base derived from isatin and thiosemicarbazides and their metal complexes are summarized.

Keywords

Schiff Base, Thiosemicarbazone and Isatin Based Metal Complexes, Antimicrobial Activity.

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