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Authors
Affiliations
1 Dept. of Pharmaceutical Chemistry, Babu Banarsi Das Institute of Technology and Management, Lucknow, UP, IN
Source
Asian Journal of Research in Chemistry, Vol 3, No 2 (2010), Pagination: 430-433
Abstract
A number of chalcones were synthesized by reacting 2-Acetyl Naphthalene, with Aryl substituted aldehydes in ethanolic NaOH, a Claisen-Schmidt condensation reaction. These chalcones were further reacted with guanidine nitrate in presence of ethanolic NaOH to obtain the amino pyrimidines. The synthesized compounds were characterized on the basis of physical, chemical and spectroscopic data and were tested for the antibacterial activity using cup plate method. Evaluation of the compounds revealed remarkable antibacterial activity. In particular, amino-pyrimidines were found to be the most effective against Bacillus subtilis and Escherichia coli bacterial strains.
Keywords
Chalcones, 2-Aminopyrimidines, Antibacterial, Guanidine Nitrate.
