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Dighade, N. R.
- Simultaneous Estimation of Cinitapride Hydrogen Tartrate (CNT) and Pantoprazole Sodium Sesquihydrate (PNP) in Capsule by Q-analysis UV- Spectrophotometric Method
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Authors
Affiliations
1 Adv. V. R. Manohar Institute of Diploma in Pharmacy, Wanadongri, Hingna Road, Nagpur–441110, IN
2 Department of Pharmaceutical Sciences, Rashtrasant Tukdoji Maharaj Nagpur University, Nagpur, IN
1 Adv. V. R. Manohar Institute of Diploma in Pharmacy, Wanadongri, Hingna Road, Nagpur–441110, IN
2 Department of Pharmaceutical Sciences, Rashtrasant Tukdoji Maharaj Nagpur University, Nagpur, IN
Source
Asian Journal of Research in Chemistry, Vol 6, No 10 (2013), Pagination: 911-915Abstract
Cinitapride and Pantoprazole are available as capsule dosage forms in the ratio 1:13.33. A simple reproducible and efficient method for the simultaneous determination of cinitapride and pantoprazole in marketed formulation was developed. The proposed method is based on the Q-analysis UV-Spectrophotometric method. The absorbance maximum of cinitapride and pantoprazole were found to be 265.5 nm and 268 nm respectively in water. In Q-analysis, the isoabsorptive point for both the drugs was found at 236 nm. The linearity range lies between 5-30 μg/ml for cinitapride and pantoprazole at their respective wavelengths. Both the drugs obey Beers law. The recovery studies confirmed the accuracy of the proposed method.Keywords
Pantoprazole, Cinitapride, Q-analysis, Simultaneous Estimation
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