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Authors
Affiliations
1 Govt. College of Pharmacy, Vidyanagar, Karad-415124, Maharashtra, IN
Source
Asian Journal of Research in Chemistry, Vol 2, No 2 (2009), Pagination: 154-156
Abstract
Three simple, precise and economical UV methods have been developed for the estimation of Esomeprazole in bulk and pharmaceutical formulations. Esomeprazole has the absorbance maxima at 303nm (Method A), and in the first order derivative spectra, showed zero crossing at 303nm, with a sharp peak at 292nm when n=1 (Method B), Method C applied was Area Under Curve (AUC) for analysis of Esomeprazole in the wavelength range of 294- 310nm. Drug followed the Beer’s Lamberts range of 5-40 μg/ml for the Method A, B C. Results of analysis were validated statistically and by recovery studies and were found to be satisfactory.
Keywords
Esomeprazole, UV Spectrophotometry, Derivative Spectroscopy, Area Under Curve.
