Asian Journal of Research in Chemistry

V. Rele Rajan ¹, P. Tiwatane Prathamesh ¹

Affiliations
1 Department of Chemistry, D.G. Ruparel College, Mahim, Mumbai 400 016, IN

Abstract

A simple precise, rapid accurate and sensitive non-aqueous potentiometric titration method was developed for quantitative determination of alprazolam from pharmaceutical dosage form. The titration was carried out using standardized 0.1 N perchloric acid. The proposed method was found to be precise with % RSD <1 (n = 6). The method showed strict linearity (r² > 0.9999 ) between 20 % to 100 % of 0.100 mg of drug substance weight. The percentage recovery of alprazolam in the optimized method was between 100.0 to 100.416 %. The method is also found to be rugged when checked by different analysts and using different lots of reagents and different makes of titrators.

Keywords

Alprazolam, Perchloric Acid, Potassium Hydrogen Phthalate, Glacial Acetic Acid.

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