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Salve, Pallavi
- Simultaneous UV-Spectrophotometric Method for Estimation of Atenolol and Losartan Potassium in Tablet Dosage Form
Abstract Views :177 |
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Authors
Rupali Kirtawade
1,
Pallavi Salve
1,
Chhotaram Seervi
1,
Kiran Patil
1,
Anita Kulkarni
1,
Pandurang Dhabale
1
Affiliations
1 Govt. College of Pharmacy, Karad-415124, (Satara), Maharashtra, IN
1 Govt. College of Pharmacy, Karad-415124, (Satara), Maharashtra, IN
Source
Asian Journal of Research in Chemistry, Vol 3, No 4 (2010), Pagination: 1050-1053Abstract
Two simple, accurate, precise, reproducible and economical procedures for simultaneous estimation of Atenolol (AT) and Losartan Potassium (LP) in tablet dosage form have been developed. First method based on solving of simultaneous equation using 226 nm (λmax of AT) and 208 nm (λmax of LP) as two analytical wavelengths for both drugs in Methanol solvent. Second method based on an equation of area calculation of curve at two wavelength region (231 to 221 nm and 213 to 203 nm). Linearity was observed in the concentration range of 6-36 μg/ml for AT and 2-16 μg/ml for LP. The results of analysis have been validated statistically and by recovery study.Keywords
Atenolol, Losartan Potassium, λmax, Simultaneous Estimation Method, Area Under Curve (AUC).- Validated Spectroscopic Method for Estimation of Aceclofenac from Tablet Formulation
Abstract Views :165 |
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Authors
Deepali Gharge
1,
Pallavi Salve
1,
Chandrakant Raut
1,
Chottaram Seervi
1,
Kundan Pawar
1,
Pandurang Dhabale
1
Affiliations
1 Government College of Pharmacy, Karad-415124, Dist Satara, M.S, IN
1 Government College of Pharmacy, Karad-415124, Dist Satara, M.S, IN
Source
Asian Journal of Research in Chemistry, Vol 3, No 1 (2010), Pagination: 87-89Abstract
Aceclofenac is a non steroidal anti-inflammatory drug with good analgesic and anti-rheumatic properties. Various methods for analysis of the same are available but are time consuming and expensive. Here we have developed a new, precise and simple UV spectrophotometric method for estimation of aceclofenac from tablet formulation. The drug obeyed the Beer’s law and showed good correlation. Absorption maxima of aceclofenac in methanol diluted with glass double distilled water was found to be at 273 nm. Beer’s law was obeyed in concentration range 2-20 mcg/ml. The results of analysis were validated by recovery studies. The recovery was more than 99%. The method was found to be simple, accurate, precise, economical and robust.Keywords
Aceclofenac, UV-Spectrophotometry, Recovery, Accuracy.- Microwave Chemistry:A Review
Abstract Views :171 |
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Authors
Affiliations
1 Government College of Pharmacy, Karad-415124, Dist Satara, M.S., IN
1 Government College of Pharmacy, Karad-415124, Dist Satara, M.S., IN
Source
Asian Journal of Research in Chemistry, Vol 3, No 1 (2010), Pagination: 9-16Abstract
Microwave chemistry involves the use of microwave radiation to conduct chemical reactions, and essentially pertains to chemical analysis and chemical synthesis. The fundamental mechanism of microwave heating involves agitation of polar molecules or ions that oscillate under the effect of an oscillating electric or magnetic field. In the presence of an oscillating field, particles try to orient themselves or be in phase with the field. Only materials that absorb microwave radiation are relevant to microwave chemistry. These materials can be categorized according to the three main mechanisms of heating, namely:Dipolar polarization, Conduction mechanism, Interfacial polarization. Microwave chemistry apparatus are classified:Single-mode apparatus and Multi-mode apparatus.Keywords
Microwave Chemistry, Microwave Synthesis, Mechanism, Advantages.- Simultaneous UV Spectrophotometric Method for Estimation of Amlodipine Besylate and Lisinopril in Tablet Dosage Form
Abstract Views :159 |
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Authors
Affiliations
1 Govt. College of Pharmacy, Karad-415124 (Satara), Maharashtra, IN
1 Govt. College of Pharmacy, Karad-415124 (Satara), Maharashtra, IN
Source
Asian Journal of Research in Chemistry, Vol 3, No 1 (2010), Pagination: 201-204Abstract
Two simple, accurate, precise, reproducible, requiring no prior separation and economical procedures for simultaneous estimation of Amlodipine Besylate and Lisinopril in tablet dosage form have been developed. First method employs formation and solving of simultaneous equation using 239 nm and 207 nm as two analytical wavelengths for both drugs in Triple distilled water. The second method is Q value analysis based on measurement of absorptivity at 212.5 nm (as an iso-absorptive point) and 239 nm. Amlodipine Besylate and Lisinopril at their respective λmax 239 nm and 207 nm and at isoabsorptive point 212.5 nm shows linearity in a concentration range of 5-30 μg/mL. Recovery studies range from 101.49% for Amlodipine Besylate and 99.27% for Lisinopril in case of simultaneous equation method and 100.76% for Amlodipine Besylate and 99.73% for Lisinopril in case of Q-analysis method confirming the accuracy of the proposed method. The proposed method is recommended for routine analysis since it is rapid, simple, accurate and also sensitive and specific.Keywords
Amlodipine Besylate, Lisinopril λmax, Simultaneous Equation Method, Q Analysis.- Simple Validated Spectroscopic Method for Estimation of Amlodipine Besylate from Tablet Formulation
Abstract Views :151 |
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Authors
Affiliations
1 Government College of Pharmacy, Karad-415124, Dist Satara, M.S., IN
1 Government College of Pharmacy, Karad-415124, Dist Satara, M.S., IN