Asian Journal of Research in Chemistry

Rupali Kirtawade ¹, Pallavi Salve ¹, Chhotaram Seervi ¹, Kiran Patil ¹, Anita Kulkarni ¹, Pandurang Dhabale ¹

Affiliations
1 Govt. College of Pharmacy, Karad-415124, (Satara), Maharashtra, IN

Abstract

Two simple, accurate, precise, reproducible and economical procedures for simultaneous estimation of Atenolol (AT) and Losartan Potassium (LP) in tablet dosage form have been developed. First method based on solving of simultaneous equation using 226 nm (λmax of AT) and 208 nm (λmax of LP) as two analytical wavelengths for both drugs in Methanol solvent. Second method based on an equation of area calculation of curve at two wavelength region (231 to 221 nm and 213 to 203 nm). Linearity was observed in the concentration range of 6-36 μg/ml for AT and 2-16 μg/ml for LP. The results of analysis have been validated statistically and by recovery study.

Keywords

Atenolol, Losartan Potassium, λmax, Simultaneous Estimation Method, Area Under Curve (AUC).

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Deepali Gharge ¹, Pallavi Salve ¹, Chandrakant Raut ¹, Chottaram Seervi ¹, Kundan Pawar ¹, Pandurang Dhabale ¹

Affiliations
1 Government College of Pharmacy, Karad-415124, Dist Satara, M.S, IN

Abstract

Aceclofenac is a non steroidal anti-inflammatory drug with good analgesic and anti-rheumatic properties. Various methods for analysis of the same are available but are time consuming and expensive. Here we have developed a new, precise and simple UV spectrophotometric method for estimation of aceclofenac from tablet formulation. The drug obeyed the Beer’s law and showed good correlation. Absorption maxima of aceclofenac in methanol diluted with glass double distilled water was found to be at 273 nm. Beer’s law was obeyed in concentration range 2-20 mcg/ml. The results of analysis were validated by recovery studies. The recovery was more than 99%. The method was found to be simple, accurate, precise, economical and robust.

Keywords

Aceclofenac, UV-Spectrophotometry, Recovery, Accuracy.

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Deepali Gharge ¹, Pallavi Salve ¹, Chandrakant Raut ¹, Kundan Pawar ¹, Pandurang Dhabale ¹

Affiliations
1 Government College of Pharmacy, Karad-415124, Dist Satara, M.S., IN

Abstract

Microwave chemistry involves the use of microwave radiation to conduct chemical reactions, and essentially pertains to chemical analysis and chemical synthesis. The fundamental mechanism of microwave heating involves agitation of polar molecules or ions that oscillate under the effect of an oscillating electric or magnetic field. In the presence of an oscillating field, particles try to orient themselves or be in phase with the field. Only materials that absorb microwave radiation are relevant to microwave chemistry. These materials can be categorized according to the three main mechanisms of heating, namely:Dipolar polarization, Conduction mechanism, Interfacial polarization. Microwave chemistry apparatus are classified:Single-mode apparatus and Multi-mode apparatus.

Keywords

Microwave Chemistry, Microwave Synthesis, Mechanism, Advantages.

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Pallavi Salve ¹, Deepali Gharge ¹, Rupali Kirtawade ¹, Pandurang Dhabale ¹, Kishor Burade ¹

Affiliations
1 Government College of Pharmacy, Karad-415124, Dist Satara, M.S., IN

Abstract

Amlodipine Besylate is a Calcium channel blocker, anti-hypertensive agent. Various methods for analysis of the same are available but are time consuming and expensive. Here we have developed a new, precise and simple UV spectrophotometric method for estimation of Amlodipine Besylate from tablet formulation. The drug obeyed the Beer’s law and showed good correlation. Absorption maxima of Amlodipine in double distilled water was found to be at 239 nm. Beer’s law was obeyed in concentration range 2-12 mcg/ml. The results of analysis were validated by recovery studies. The recovery was more than 99%. The method was found to be simple, accurate, precise, economical and robust.

Keywords

Amlodipine Besylate, UV Spectrophotometry, Recovery, Accuracy.

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