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Modiya, Priya R.
- Foldamers are Artificial Molecular Architectures Inspired by Biopolymers Which can hold the Molecules in the Matrix by Non-Covalent Interactions
Authors
1 Department of Pharmaceutical Chemistry, Shri Sarvajanik Pharmacy College, Gujarat Technological University, Arvind Baug, Mehsana-384001, Gujarat, IN
Source
Asian Journal of Research in Chemistry, Vol 4, No 1 (2011), Pagination: 13-23Abstract
Biological macromolecules are composed of one or more linear oligomers that fold into a functional form. The information that governs the final structure is encoded in the sequence of monomers and the precise functionality that they display, but accurate prediction of such structures remains a major challenge in structural biology. Recently, chemists have begun to develop small molecule systems that fold in a similar way and these may help to answer more complex questions or find applications in artificial molecular assemblies. Study of the properties of a family of oligoamides composed of alternating repeats of isophthalic acid and bisaniline building blocks have a rich supramolecular chemistry in non-polar solvents, forming macrocyclic receptors, catenanes, knots and double-stranded zipper complexes via a combination of amide–amide hydrogen bonds and aromatic interactions. Here the serendipitous discovery of a new member of the family that folds into a well-defined, compact, three-dimensional structure, governed by a combination of hydrogen bonding and aromatic interactions.
Keywords
Macromolecules, Oligomers, Biopolymers, Folder Polymers, Matrix Interactions.- 10-15≈FEMTOChemistry:New Frontier Exponent after NANOChemistry
Authors
1 Department of Pharmaceutical Chemistry, Shri Sarvajanik Pharmacy College, Gujarat Technological University, Arvind Baug, Mehsana-384001, Gujarat, IN