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Authors
Affiliations
1 JKK Nataraja College of Pharmacy, Komarapalayam, Namakkal District, Tamil Nadu 638183, IN
2 Nandha College of Pharmacy, Erode, Tamil Nadu 638 052, IN
3 Department of Pharmaceutics, Seventh of April University, Al-Zawia City, LY
4 Vinayaka Missions College of Pharmacy, Salem, Tamil Nadu, IN
Source
Asian Journal of Research in Chemistry, Vol 4, No 1 (2011), Pagination: 110-113
Abstract
The study was aimed at evaluating the antitumor and antioxidant activities of ethanol extract of Pseudarthria viscida (Family: Fabaceae) against Ehrlich ascites carcinoma (EAC)-bearing Swiss albino mice. The ethanol extract of Pseudarthria viscida (EEPV) was administered at the doses of 100 and 200 mg/kg in mice for 14 days after 24 h of tumor inoculation. The effect of EEPV on the growth of transplantable murine tumor, life span of EAC bearing mice, hematological profile and liver biochemical parameters were estimated. Treatment with EEPV decreased the tumor volume and viable cell count thereby increasing the life span of EAC bearing mice and brought back the hematological parameter more or less normal level. The effect of EEPV decreases the level of lipid peroxidation and protein content and significantly increased the level of antioxidant enzymes such as Catalase (CAT), Glutathione (GSH) and Superoxide dismutase (SOD). These observations are suggestive of the protective effect of EEPV against Ehrlich Ascites Carcinoma (EAC).
Keywords
Pseudarthria viscida, Ehrlich Ascites Carcinoma, Hematological Parameter, Antioxidant, Antitumor Activity.
