Asian Journal of Research in Chemistry

M. Sundarapandian ¹, S. Venkataraman ², R. Xavierarulappa ², M. Boopathi ¹, S. Selvakumar ²

Affiliations
1 Department of Pharmaceutical Analysis, K.M. College of Pharmacy, Uthangudi, Madurai-625107, IN
2 Department of Pharmaceutical Chemistry, K.M. College of Pharmacy, Uthangudi, Madurai-625107, IN

Abstract

A simple, rapid, economical and sensitive visible spectrophotometric method for the estimation of Meloxicam has been developed based on the formation of ion-pair of Meloxicam with dye bromocresol green in acidic medium, which was extracted into chloroform. It has absorption maxima at 415 nm. Beer’s law limit was found to be 10-50 mcg/ml. The molar absorptivity was found to be 2.17×10³ (mole^-1cm^-1) and sandell’s sensitivity was 0.1612 (μg/cm²/0.001 absorbance unit). The correlation coefficient (r) was found to be 0.9999. The limit of detection (LOD) and limit of quantification (LOQ) was found to be 0.88 and 2.69 mcg/ml respectively of Meloxicam. The result of estimation in marketed formulations was found to be 99.86±0.32 and 97.93±0.32. The proposed method was applied successfully for the determination of Meloxicam in tablets with average recovery of 99.62±0.88 and 100.4±0.768. The method was then validated statistically as per ICH guidelines, which yielded good results concerning range, linearity, precision and accuracy.

Keywords

Meloxicam, Bromo Cresol Green, Spectrophotometry.

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