Asian Journal of Research in Chemistry

Rajat S. Pathak ¹, Amiya Shekhar ¹, Devendra D. Pathak ¹

Affiliations
1 Department of Applied Chemistry, Indian School of Mines, Dhanbad-826004, Jharkhand, IN

Abstract

One pot, four-component condensation of an aryl aldehyde, acetyl chloride, acetophenone and acetonitrile in the presence of Copper(II) chloride dihydrate is reported. Copper(II) chloride as an inexpensive, efficient, and readily available catalyst for the synthesis of β-acetamido ketones in high yields. The products obtained were clean and devoid of any undesired impurities as evident from ¹H NMR, IR, and TLC analysis.

Keywords

Aryl Aldehyde, Acetyl Chloride, Acetophenone, Copper(II) Chloride, β-Acetamido Ketones.

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