Asian Journal of Research in Chemistry

M. Mushfiq ¹, G. Mudgal ¹, Rakhshanda Rehman ¹, Sultanat ¹

Affiliations
1 Department of Chemistry, Aligarh Muslim University, Aligarh (U.P) 202002, IN

Abstract

The reaction of steroidal epoxides with a mixture of silica gel and sodium chloride gave the products which were confirmed by elemental analysis and spectral data (IR, ¹HNMR, ¹³CNMR). The method is economical, environmentally friendly, convenient, one pot transformation of epoxides.

Keywords

Solid Support Silica Gel, Steroidal Epoxides, Sodium Chloride.

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M. Mushfiq ¹, Sultanat ¹, Rakhshanda Rehman ¹

Affiliations
1 Department of Chemistry, Aligarh Muslim University, Aligarh-202002, U.P, IN

Abstract

The dimeric steroids have been shown to exhibit such unique characteristics as detergents, medicinal, catalytic and liquid crystal properties that will lead to important applications. New dimeric steroids 1,3 (bicholest-5-enyl-3,3'-dioxy) propane (5) and 1,3 (bistigmasta-5,22-dienyl-3,3'-dioxy) propane (6) along with cholesta-4,6-diene (7) and stigmasta-4,6,22-triene (8) are synthesized by the treatment of acetic acid and CuCl₂ with 1,3-dibromopropane which is proving to be a good reagent for such dimerizations. The structures (5) and (6) are supported by their physical and spectral properties (IR, ¹HNMR, C¹³NMR and mass) and Rast’s method.

Keywords

Steroidal Alkenes, Dimeric Steroids, 1,3-Dibromopropane, Cupric Chloride, P-Toluenesulphonylchloride.

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