Asian Journal of Research in Chemistry

Nachiket S. Dighe ¹, Ravindra B. Saudagar ², Ramesh S. Kalkotwar ³, D. A. Jain ⁴

Affiliations
1 Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy, Loni, MS-413736, IN
2 Department of Pharmaceutical Chemistry, R.G.Sapkal College of Pharmacy, Nashik, M.S., IN
3 Department of pharmaceutical Chemistry, S.N.D. College of Pharmacy, Yeola, Dist-Nashik, MS, IN
4 Department of Pharmaceutical Sciences and Research, Bhagwant University, Ajmer, Rajasthan, IN

Abstract

Triazole is a five membered heterocyclic system consisting of two carbon atoms and three nitrogen atoms shows wide range of biological activities. Triazoles can be synthesized using Einhorn-Brunner reaction or the Pellizzari reaction from acyl hydrazides. Triazoles posses wide spectrum of biological activities like including antibacterial, antifungal, antiviral, anti-inflammatory, anticonvulsant, antidepressant, antihypertensive, analgesic, and hypoglycemic properties. The present reviews attempted to gather the various developments in synthesis and biological activities of triazole derivatives.

Keywords

1, 2, 4-Triazole, Pharmacological Activity, SAR, Total Synthesis.

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Prajakta A. Kokane ¹, Bhushan A. Bhairav ¹, Ravindra B. Saudagar ²

Affiliations
1 Department of Quality Assurance Techniques, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik, IN
2 Department of Pharmaceutical Chemistry, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik, IN

Abstract

Analytical methods development and validation play important roles in the discovery, development, and manufacture of pharmaceuticals. Simple, precise and accurate UV spectroscopic method has been developed and validated for estimation of Benazepril Hydrochloride. It is a angiotensin converting enzyme inhibitors. UV spectroscopic method which is based on measurement of absorption of UV light, the spectra of Benazepril Hydrochloride in methanol showed maximum wavelength at 237 nm and calibration curve were plotted over the concentrations ranging from 2-22ug/ml of Benazepril Hydrochloride with correlation coefficient 0.961 validation was performed as per ICH Q2 (R1) guidelines for linearity, accuracy, precision and recovery. The proposed method was validated.

Keywords

Benazepril Hydrochloride, Methanol, Water, Co-Solvency Method, Spectrophotometer and Validation.

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Pinak S. Paralkar ¹, Dattatraya M. Shinkar ¹, Ravindra B. Saudagar ²

Affiliations
1 Department of Pharmaceutics, KCT'S R.G. Sapkal College of Pharmacy, Anjenari, Dist. Nashik-422212, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, KCT'S R.G. Sapkal College of Pharmacy, Anjenari, Dist. Nashik-422212, Maharashtra, IN

Abstract

Sharpless enantioselective epoxidation of achiral primary allyl alcohols is one of the best reaction discovered during the last about three decades. The reaction was typically named after discovery of this by Karl Barry Sharpless. For this discovery Sharpless received the Nobel Prize for medicinal chemistry in the year 2001. This reaction is stearoselective, i.e. it produces only enantionmers as final product. This reaction converts primary and secondary allylic alcohols into the 2, 3 epoxy alcohols. The final enantionmers which is formed will be a stereoselective depending upon the catalyst used during the same reaction. This reactions turns to be industry beneficial due to its applicability and high yield of products in the reaction.

Keywords

Sharpless Epoxidation, 2, 3 Epoxy Alcohols, Application of Reaction, Industrial Examples.

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