Asian Journal of Research in Chemistry

Rele Rajan V ¹, Tiwatane Prathamesh P ¹

Affiliations
1 Central Research Laboratory D.G. Ruparel College Mahim, Mumbai 400 016., IN

Abstract

A simple precise, rapid accurate and sensitive non-aqueous potentiometric titration method was developed for quantitative determination of favipiravir from pharmaceutical dosage form. The titration was carried out using standardized 0.1 N perchloric acid. The proposed method was found to be precise with % RSD <1 (n = 6). The method showed strict linearity (r2 > 0.9999) between 10 % to 50 % w/v of 0.200 mg of drug substance weight. The percentage recovery of favipiravir in the optimized method was between 99.65 to 100.08 %. The method is also found to be rugged when checked by different analysts and using different lots of reagents and different makes of titrators.

Keywords

Favipiravir, Perchloric acid, Potassium hydrogen phthalate, Glacial acetic acid.

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Rele Rajan V ¹, Tiwatane Prathamesh P ¹

Affiliations
1 Central Research Laboratory, D.G. Ruparel College, Mahim, Mumbai 400 016., IN

Abstract

Simple and accurate extractive colorimetric method was developed for the estimation of molnupiravir in Pharmaceutical dosage forms. The method was based on the formation of colored ion pair complexes by the drugs with thiocynate ions. These ion pair complexes were quantitatively extracted under the experimental condition in organic solvent like chloroform. The absorbance values were measured at 620 respectively. The proposed method was validated statistically. A recovery of method was carried out by standard addition methods. The Beer’s law ranges were found to be 1-14 μg/ml, respectively. The low values of standard deviation and percentage RSD indicate high precision of method. Hence the method is useful for routine estimation of molnupiravir in tablets respectively.

Keywords

Molnupiravir, Cobalt nitrate, Ammonium thiocynate, Chloroform, ethanol.

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Rele Rajan V ¹, Tiwatane Prathamesh P ²

Affiliations
1 Central Research Laboratory, D. G. Ruparel College, Mahim, Mumbai - 400 016 ., IN
2 Central Research Laboratory, D. G. Ruparel College, Mahim, Mumbai - 400 016., IN

Abstract

Simple sensitive and accurate extractive spectrophotometric methods have developed for the estimation of favipiravir in pharmaceutical dosage form. The methods are based on the formation of coloured complexes by the drug with reagents like bromophenol blue, solochrome dark blue and bromocresol green in acidic medium. The ion associated complexes were formed and quantitatively extracted under the experimental condition in chloroform. The absorbance values were measured at 420nm, 495nm and 430nm respectively. The proposed methods were validated statistically. Recoveries of methods were carried out by standard addition methods. The linearity was found to be 1.0-12.0μg/ml, 2-20μg/ml, 1-16μg/ml for methods 1, 2 and 3 respectively. The low values of standard deviation and percentage RSD indicate high precision of methods. Hence these methods are useful for routine estimation of favipiravir in tablets

Keywords

Favipiravir, Bromophenol blue, solochrome dark blue, Bromocresol green, Chloroform ethanol.

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Rele Rajan V ¹, Tiwatane Prathamesh P ²

Affiliations
1 Central Research Laboratory, D.G. Ruparel College Mahim Mumbai 400 016., IN
2 Central Research Laboratory, D.G. Ruparel College Mahim Mumbai 400 016 ., IN

Abstract

A simple precise, rapid accurate and sensitive non-aqueous potentiometric titration method was developed for quantitative determination of molnupiravir from pharmaceutical dosage form. The titration was carried out using standardized 0.1 N perchloric acid. The proposed method was found to be precise with % RSD <1 (n = 6). The method showed strict linearity (r2 > 0.9999) between 10 % to 50 % w/v of 100 mg of drug substance weight. The percentage recovery of molnupiravir in the optimized method was between 99.05 to 99.81 %. The method is also found to be rugged when checked by different analysts and using different lots of reagents and different makes of titrators.

Keywords

Molnupiravir, Perchloric acid, Potassium hydrogen phthalate, Glacial acetic acid.

Full Text