Asian Journal of Research in Chemistry

Sujata J. Gondane ¹, M. P. Mahajan ¹, S. D. Sawant ¹

Affiliations
1 Department of Pharmaceutical Chemistry, STES’S, Smt. Kashibai Navale College of Pharmacy, Kodhwa, Pune - 411048, IN

Abstract

The present study deals with UV spectrophotometric method development and Validation for estimation of Tizanidine and Aceclofenac in bulk drug and tablet dosage form by absorption correction by interference method. The method is based on by using two wavelengths, 274 nm for aceclofenac and 318 nm for Tizanidine. The Linearity of Tizanidine and Aceclofenac was found to be in the range 0f 2-10 μg/ml and 5-25 μg/ml respectively. The % recovery of Tizanidine and Aceclofenac was found out to be 98-102 % respectively. The proposed method was validated as per ICH guidelines.

Keywords

Aceclofenac, Tizanidine, Absorption Correction Method.

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S. D. Sawant ¹, R. N. Patil ², A. A. Baravkar ³

Affiliations
1 Sinhgad Technical Education Society’s Smt. Kashibai Navale College of Pharmacy, Department of Pharmaceutical Chemistry, Kondhwa (Bk), Pune 411 048, IN
2 SVPM’s College of Pharmacy, Malegaon (Bk), Baramati, Pune 413 115, IN
3 Karpagam University, Coimbatore, Tamil Nadu, IN

Abstract

In current study, 2,4,5-trisubstituted-1H-imidazoles have been synthesized by starting from acid chloride preparation of various aromatic acetic acids (Ar’) such as 1-naphthyl acetic acid and 4-biphenyl acetic acid, which are used as such for the Friedel–Craft acylation (FCA) using various substituted aromatic nucleus (1a-b) (Ar) such as anisole, thioanisole etc and anhydrous aluminium trichloride to get various ethanone derivatives (2c-d). Methylsulfanyl group is converted into methylsulfonyl by refluxing former with glacial acetic acid and hydrogen peroxide to get ethanone derivatives containing methylsulfonyl moiety (2e-f). These ethanone derivatives (2a-f) were subjected to microwave irradiation for 90 secs to obtain diketones or ethanediones (3a-f). Ethanediones, in presence of acetic acid, ammonium acetate and benzaldehyde offered targeted compounds (4a-f). The structural elucidation of synthesized compounds was done using IR as well as ¹H NMR spectroscopy and biological screening for antibacterial action using E. coli and S. aureus and antifungal action using C. albicans and C. fumigatus was done using cup plate agar diffusion method.

Keywords

1H-Imidazole, Microwave Irradiation, Antibacterial, Antifungal.

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