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Pattan, S. R.
- Significance of Fluorine in Medicinal Chemistry:A Review
Abstract Views :190 |
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Authors
Affiliations
1 Department of Medicinal Chemistry, Pravara Rural College of Pharmacy, Pravaranagar, M.S, IN
1 Department of Medicinal Chemistry, Pravara Rural College of Pharmacy, Pravaranagar, M.S, IN
Source
Asian Journal of Research in Chemistry, Vol 2, No 4 (2009), Pagination: 376-379Abstract
Fluorine is second smallest element in periodic table. It has many pharmacological activities with different substituted heterocycles. It has attracted the attention of Medicinal Chemist for its versatile and significant activities. This review explains the significance of presence of fluorine in various Medicinal compounds. The medicinal importance, use of the drugs containing fluorine is listed.Keywords
Fluorine, Haloperidol, Progabide.
- Synthesis and Evaluation of Some New Phenyl Thiazole Derivatives for Their Anti-Microbial Activities
Abstract Views :157 |
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Authors
S. R. Pattan
1,
R. L. Hullolikar
1,
J. S. Pattan
2,
N. S. Dighe
1,
M. B. Hole
1,
S. H. Kale
1,
S. B. Bhawar
3
Affiliations
1 Department of Medicinal Chemistry, Pravara Rural College of Pharmacy, Pravaranagar, Loni-413713, IN
2 Department of Biotechnology, P V P Science College, Pravaranagar, Loni-413713, IN
3 Department of Pharmacology, Pravara Rural College of Pharmacy, Pravaranagar, Loni-413713, IN
1 Department of Medicinal Chemistry, Pravara Rural College of Pharmacy, Pravaranagar, Loni-413713, IN
2 Department of Biotechnology, P V P Science College, Pravaranagar, Loni-413713, IN
3 Department of Pharmacology, Pravara Rural College of Pharmacy, Pravaranagar, Loni-413713, IN
Source
Asian Journal of Research in Chemistry, Vol 2, No 3 (2009), Pagination: 292-296Abstract
Fifteen novel derivatives of phenyl thiazole derivatives were synthesized. The synthesized compounds were tested for their preliminary tests, physical constants, TLC, solubility, etc. the structures of the final compounds were confirmed by IR, 1H-NMR Spectra and CHN analysis. The proposed compounds were screened for their antimicrobial, antifungal, activities with the standard drugs.- Synthesis and Evaluation of Some New Substituted 1, 4-Dihydropyridine Derivatives and Their Anti-Inflammatory Activity
Abstract Views :156 |
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Authors
S. R. Pattan
1,
N. S. Dighe
1,
S. V. Hiremath
2,
A. N. Merekar
3,
V. M. Gaware
1,
D. S. Musmade
1,
P. M. Gaikwad
4
Affiliations
1 Dept of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy, Pravaranagar, Loni-413713, IN
2 Dept of Pharmacology, J.N Medical College, Belgaum, IN
3 Dept of Pharmaceutics, Pravara Rural College of Pharmacy, Pravaranagar, Loni-413713, IN
4 Dept of Pharmacology, Pd. Dr. Vitthalrao Vikhe Patil College of Pharmacy, Ahmednagar, IN
1 Dept of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy, Pravaranagar, Loni-413713, IN
2 Dept of Pharmacology, J.N Medical College, Belgaum, IN
3 Dept of Pharmaceutics, Pravara Rural College of Pharmacy, Pravaranagar, Loni-413713, IN
4 Dept of Pharmacology, Pd. Dr. Vitthalrao Vikhe Patil College of Pharmacy, Ahmednagar, IN
Source
Asian Journal of Research in Chemistry, Vol 2, No 3 (2009), Pagination: 310-313Abstract
A new series if substituted 1, 4-Dihydropyridine derivatives were synthesized and the structures of these compounds were established on the basis of spectral and elemental analysis. All the compounds were evaluated for anti-inflammatory activity by paw edema, xylene induced ear edema and cotton wool granuloma methods. Compounds C4, C5, C6, C7 and C9 have been found to exhibit excellent anti-inflammatory activity.Keywords
1, 4-Dihydropyridine, Anti-Inflammatory, CHN Analysis.- RP- HPLC Method for Simultaneous Estimation of Pseudoephidrine Sulphate and Desloratidine from Bulk and Tablets
Abstract Views :158 |
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Authors
Affiliations
1 Pravara Rural College of Pharmacy, Pravaranagar, Dist. Ahemadnagar 413 736. (MS), IN
1 Pravara Rural College of Pharmacy, Pravaranagar, Dist. Ahemadnagar 413 736. (MS), IN
Source
Asian Journal of Research in Chemistry, Vol 2, No 2 (2009), Pagination: 139-142Abstract
A simple, selective, rapid, precise and economical reverse phase high-pressure liquid chromatographic method has been developed for the simultaneous estimation of Pseudoephidrine sulphate and Desloratidine from pharmaceutical formulation by using internal standard Nabumetone. The method was carried out on a HiQ sil C18 W (250mm x 4.6 mm) column, with a mobile phase consisting of Acetonitrile: Methanol :Ammonium acetate (45:40:15 v/v) at a flow rate of 1.5 ml/min. Detection was carried out at 265 nm. The retention time of Pseudoephidrine sulphate, Desloratidine, and Nabumetone were 2.067, 3.050 and 3.750min. Respectively. The developed method was validated in terms of accuracy, precision, linearity, Limit of detection, Limit of quantitation. The proposed method can be used for estimation of these drugs in combined dosage form for routine analysis.Keywords
Pseudoephidrine Sulphate, Desloratidine, Nabumetone, RP-HPLC.- Synthesis and Biological Evaluation of Some Substituted Amino Thiazole Derivatives
Abstract Views :155 |
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Authors
Affiliations
1 Department of Medicinal Chemistry, Pravara Rural College of Pharmacy, Pravaranagar, IN
2 Department of Pharmacognosy, Pravara Rural College of pharmacy, Pravaranagar, IN
3 Department of Pharmaceutics, Pravara Rural College of Pharmacy, Pravaranagar, IN
1 Department of Medicinal Chemistry, Pravara Rural College of Pharmacy, Pravaranagar, IN
2 Department of Pharmacognosy, Pravara Rural College of pharmacy, Pravaranagar, IN
3 Department of Pharmaceutics, Pravara Rural College of Pharmacy, Pravaranagar, IN
Source
Asian Journal of Research in Chemistry, Vol 2, No 2 (2009), Pagination: 196-201Abstract
Thiazoles and their derivatives exhibit a wide variety of biological activities like antidiabetic, anti inflammatory, anticonvulsants etc.
In the present study we have synthesized some substituted thiazoles. These compounds were evaluated for various biological activities like Anti-diabetic,anti-inflammatory,anti-fungal activity.