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Mohan, S.
- Synthesis, Characterization and Antimicrobial Activity of Some Schiff Bases of 2-amino-4-(4-chlorophenyl)–n-(3-furan-2-ylmethyl carboxamido) thiophenes
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Authors
Affiliations
1 Department of Pharmaceutical Chemistry, PES College of Pharmacy, Bangalore-50, Karnataka, IN
1 Department of Pharmaceutical Chemistry, PES College of Pharmacy, Bangalore-50, Karnataka, IN
Source
Asian Journal of Research in Chemistry, Vol 6, No 1 (2013), Pagination: 24-28Abstract
2-amino-4-(4-chlorophenyl)-N-(3-furan-2-ylmethyl carboxamido) thiophenes was synthesized using versatile Gewald reaction .First step is preparation of furfuryl cyanoacetamide which was carried out by condensation of furfuryl amine and ethyl cyano acetate which was then reacted with p-chloro acetophenone, sulphur, diethyl amine to give 2-amino-4-(4- chlorophenyl)-N-(3-furan-2-yl methyl carboxamido) thiophene (SM-4) later the compound was treated with twelve different substituted aryl aldehydes to yield twelve new Schiff bases(SM 4a-4l). The compounds were characterized IR, 1H NMR and mass spectral data and screened for antimicrobial activity.Keywords
Synthesis, Thiophenes, Schiff Bases, Spectral Analysis, Antimicrobial ActivityReferences
- Sara T, Tahmineh, Mohammed R.F. Synthesis, and antimicrobial activity of 1-[1,2,4-triazol-3yl] and 1-[1,3,4-thiadiazol-2-yl]- 3methylthio-6,7-dihydro-benzo[c] thiophenes-4[5H]ones. Bioorg Med Chem Lettr 2005;15:1023-25.
- Ajay DP, Parendu DR, Franklin PX, Harish P,Vasudevan S, Kamala KV. Tetra substituted thiophenes as anti-inflammatory agents: Exploitation of analogue-based drug design. Bioorg Med Chem Lettr 2005; 13:6685-92.
- Bhattacharjee S et al. Synthesis, Characterization and CNS depressant activity of some schiff bases of 2-amino-4-(4- chlorophenyl) thiophene-3 carboxamide. Asian J of Res Chem. 2011; 4(10):1562-65.
- Pinto E,Queiroz M.J, Vale-Silva L, Oliveira J, Begouin A, Antifungal activity of synthetic di(hetero) arylamines based on the benzo[b]thiophene moiety. Bioorg Med Chem 2008;16:8172– 8177.
- Srinivas R,Sarvanan J,Mohan S, Synthesis of 2-substitutedamino- 3(N-o-tolylcarboxamido)-4,5-dimethyl thiophenes as analgesic and anti-inflammatory agents. Indian J Hetero Chem.1998;8:59-62.
- Kristina S, Marijeta K, Ivo P, Grace K. Synthesis, photochemical synthesis, DNA binding and antitumour evaluation of novel cyano-amidino-substituted derivatives of naptha-furans, napthathiophenes, thieno benzofurans,benzo-dithiophenes and their acyclic precursors. Eur J Med Chem.2006; 41:1-15.
- Lina Li,Lei Chang, Stephane P.R, Francois L, Marc L, Rene B, Yuqing Wu. Synthesis and evaluation of benzo[b]thiophene derivatives as inhibitors of alkaline phosphatise. Bioorg. Med. Chem. 2009; 3:7290-7300.
- Isloor AM, Kalluraya B, Pai KS. Synthesis, characterization and biological activities of some new benzo[b]thiophene derivatives. Eur J Med Chem 2010;45:825–30.
- Bhandari S, Bothara K, Raut M, Patil A, Sarkate A, Mokale V. Design, synthesis and evaluation of anti-inflammatory, analgesic and ulcerogenicity studies of novel substituted phenacyl-1,3,4- oxadiazole-2-thiol and Schiff bases of diclofenac acid as non ulcerogenic derivatives, Bioorg Med Chem 2008;16:1822–1831.
- Chinnasamy R. P.; Sundararajan R.; Govindaraj S.; Synthesis, characterization and anticonvulsant activity of novel schiff base Of isatin derivatives. Int Jour Pharm Sci 2010; 2:177-181.
- Bhattacharjee S, Sarvanan J, Mohan S,Arora M. Synthesis, Charaterization and CNS depressant activity of some schiff bases of 2-amino-4-(4-chlorophenyl) thiophene-3 carboxamide. Asian J of Res Chem.2011;4(10):1562-65.
- Barry A L, Antimicrobial susceptibility test, principle and practices (Illus lea and fehinger, Philedepephia USA) 1976, pp 93-108.
- Synthesis, Characterization and Antimicrobial activity of Some Flavones
Abstract Views :350 |
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Authors
Affiliations
1 Dept. of Chemistry, Bapatla Engineering College, Bapatla (Autonomous)-522101, Andhra Pradesh, IN
2 Dept. of Chemistry, St’Anna’s Engineering College, Chirala -523156, Andhra Pradesh, IN
1 Dept. of Chemistry, Bapatla Engineering College, Bapatla (Autonomous)-522101, Andhra Pradesh, IN
2 Dept. of Chemistry, St’Anna’s Engineering College, Chirala -523156, Andhra Pradesh, IN
Source
Asian Journal of Research in Chemistry, Vol 6, No 2 (2013), Pagination: 163-165Abstract
Flavonoids are ubiquitous in photo synthesizing cells and are commonly found in fruit, vegetables, nuts, seeds, stems, flowers, tea, wine, propolis and honey. For centuries, preparations containing these compounds as the principle physiologically active constituents have been used to treat human diseases. These are abundant in polygonaceae, rutaceae, leguminosae, umbelliferae and compositae. 2(subtituted phenyl) - 4H- Chromen - 4 - one's were synthesized from substituted chalcones. The compounds obtained were identified by spectral data and screened for antimicrobial activity.Keywords
Chalcone, synthesis, flavonoids, antimicrobial activity, IR and 1H-NMR Spectral DataReferences
- Amic D, Davidovic-Amic D, Beslo D, Rastija V, Lucic B and Trinajstic N. SAR and QSAR of the antioxidant activity of flavonoids. Curr Med Chem.14 (7); 2007: 827-845.
- Pietta PG. Flavonoids as antioxidants. J Nal Prod. 63(7); 2000: 1035-1042.
- Kim HP, Son KH, Chang HW and Kang SK. Anti-inflammatory plant flavonoids and cellular action mechanisms. J Pharmacol Sci. 96; 2004: 229-245.
- Mills S and Bone K. Principles and practice of phytotherapy- Modern Herbal Medicine. New York: Churchill Livingstone. 2000: 31-34.
- Rice-Evans CA, Miller NJ and Paganga G. Structure – antioxidant activity relationship of flavonoids and phenolic acids. Free Rad Bio Med. 20(7); 1996: 933-956.
- Rice-Evans C. Flavonoids as antioxidants. Curr Med Chem. 8(7); 2001: 797-807.
- Pietta PG. Flavonoids as antioxidants. J Nat Prod. 63(7); 2000: 1035-1042.
- Chan ECH, Patchareewan P and Owen LW. Relaxation to flavonols in rat isolated thoracic aorta: Mechanism of action and structure activity relationships. J Cardiovasc Pharmacol.35 (2); 2000: 326-333.
- De Almeida ER, Xavier HS, Chaves TM, Couto GBC, Aragao- Neto AC, Silva AR and Da Silva LLS. Anxiolytic and anticonvulsant effect of dioclenol flavonoids isolated from stem bark of dioclea grandiflora on mice. International journal of Applied Research and Natural Products. 2(4); 2009-10: 44-51.
- Shin JS, Kim KS, Kim MB, Joeng JH and Kim BK. Synthesis and hypoglycemic effect of chrysin derivatives. Bioorg Med Chem Lett. 9(6); 1999: 869-874.
- Proestos C, Boziaris IS and Nychas JE. Analysis of Flavonoids and Phenolic Acids in Greek Aromatic Plants:Investigation of their Antioxidant capacity and antimicrobial activity. Food Chem. 93; 2005: 1998-2004.
- Yenjai C, Prasanphen K, Daodee S and Kittakoop P. Bioactive flavonoids from Kaempherilia Parviflora. Fitoterapia. 75; 2004: 89-92.
- Xia Y, Yang ZY, Xia P, Bastow KF, Nakanishi Y and Lee KH. Antitumor agents. Part 202: Novel 2’-Amino Chalcones: Desing, Synthesis and Biological Evaluation. Bioorganic and Medicinal Chemistry Letters.10; 2000: 699-701.
- Kumar KH and Perumal PT. A novel one-pot oxidative cyclization of 2’-amino and 2’-hydroxyl chalcones employing FeCl3.6H2O-Methanol. Synthesis of 4-alkoxy-2-aryl-quinolines and flavones. Tetrahedron. 63(38); 2007: 9531-9535.
- Ballesteros JF, Sanz MJ, Ubeda A, Miranda MA, Iborra S, Paya M and Alcaraz MJ. Synthesis and pharmacological evaluation of 2-hydroxy chalcones and flavones as inhibitors of inflammatory Mediators. J Med Chem. 38(14); 1995: 2794-2797.
- Varma RS, Saini RK and Kumar D. An Expeditious Synthesis of Flavones on Montmorillonite K- 10 Clay with microwaves. J Chem Res (S). 30(13); 1999: 348-349.
- Miao H and Yang Z. Regiospecific carbonylative annulations of iodophenol acetates and acetylenes to construct the flavones by a new catalyst of palladium-thiourea-dppp complex. Org Lett. 2(12); 2000: 1765-1768.
- Bennerdi DO, Romanelli GP, Jios JL, Autino JC, Baronetti GT and Thomas HJ. Synthesis of substituted flavones and chromens using a Wells-Dawson heteropoly acid as catalyst. Arkivoc. XI; 2008: 123-130.
- Saisivam S and Kishan VB. Standard method of antifungal activity. Ind J. Microbio. 46 (2); 2006: 13-19.
- Wader SJ, Tapas AR and Yeole PG. Studies on synthesis and antioxidant activity of some new flavonols. Int J Chem Sci. 4(4); 2006: 761-766.
- Synthesis, Characterization and CNS Depressant Activity of Some New Mannich Bases Derivatives
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Authors
Affiliations
1 Department of Pharmaceutical Chemistry, PES College of Pharmacy, Bangalore-50, Karnataka, IN
1 Department of Pharmaceutical Chemistry, PES College of Pharmacy, Bangalore-50, Karnataka, IN
Source
Asian Journal of Research in Chemistry, Vol 6, No 3 (2013), Pagination: 244-247Abstract
The novel 2-amino-3-carbethoxy-4- phenyl thiophene was synthesized by using a acetophenone and ethyl cyano acetate and the parent compound was reacted with chloroacetic acid and glacial acetic acid, the chloro compound was then substituted with different substituted primary and secondary amines to obtain a series of title compounds [SBJa 1-8]. All the new title compounds were characterized by spectral data and were screened for CNS depressant activity. In conclusion, it can be inferred that the electron donating groups on the phenyl ring at R of the title compounds influenced the CNS depressant activityKeywords
Synthesis, Thiophene, Manich Base, Characterization, CNS Depressant ActivityReferences
- Isloor AM, Kalluraya B, Pai KS. 2010; Synthesis, characterization and biological activities of some new benzo[b]thiophene derivatives. Eur J Med Chem.; 45:825–30
- Pinto E, Queiroz MJRP, Vale-Silva LA, Oliveira JF, Begouin A, Begouin JM, et al. 2008; Antifungal activity of synthetic di(hetero)arylamines based on the benzo[ b ]thiophene moiety. Bioorg Med Chem.; 16:8172–7
- Issa M.I Fakhr, Mohamed A.A. Radwan,Seham EI-Batran, Omar M.E, Abd El-Salam, Siham M.El-Shenawy. 2009; Synthesis and pharmacological evaluation of 2-substituted benzo[b]thiophenes as anti-inflamatory and analgesic agents. Eur J Med Chem. 44:1718-1725
- D.T. Connor, W.A. Cetenko, M.D. Mullican, R.J. Sorenson, P.C. Unangst, R.J. Weikert, R.L. Adolphson, J.A. Kennedy, D.O. Thueson, C.D. Wright, M.C.Conroy, 1992; J. Med. Chem.35; 958
- S.I. Graham, K.I. Shepard,P.S. Anderson,J.J. Baldwin, D.B. Best, M.E. Christy,M.B. Freedman, P. Gautheron, C.N. Habecker, 1989; J. Med. Chem.32 ,2548-2554.
- Andrey E.S, Valeria A.G, Lyubov G.D, Yuri N.L, Yuri B.S, Leonid V.K, 2009; Synthesis and Cytotoxic properties of 4,11- bis(aminoethyl)amino]anthra-[2,3-b]thiophene-5,10-diones,novel analogues of antitumor anthacene-9,10-diones. Bioorg Med Chem.; 1861-1869
- Lina Li, Lei Chang, Stephane P.R, Francois L, Marc L, Rene B, Yuqing Wu. 2009; Synthesis and evaluation of benzo[b]thiophene derivatives as inhibitors of alkaline phosphatise. Bioorg Med Chem.; 7290-7300.
- M.A. Gouda, M.A.Berghot, Ghada E,Abd EI.G, A.m. Khalil. 2010; Synthesis and antimicrobial activities of some new thiazole and pyrazole derivatives based on 4,5,6,7-tetrahydrothiophene moiety. Eur J Med Chem.; 1-8
- Synthesis, Characterization and CNS Depressant Activity of Some Schiff Bases of 2-Amino-4-(4-Chlorophenyl)Thiophene-3carboxamide
Abstract Views :149 |
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Authors
Affiliations
1 Department of Pharmaceutical Chemistry, PES College of Pharmacy, Bangalore-50, Karnataka, IN
1 Department of Pharmaceutical Chemistry, PES College of Pharmacy, Bangalore-50, Karnataka, IN
Source
Asian Journal of Research in Chemistry, Vol 4, No 10 (2011), Pagination: 1562-1565Abstract
2-amino-4-(4-chlorophenyl)thiophene-3carboxamide was synthesized using versatile Gewald reaction conditions started with the preparation of acetamide, which was carried out by cold condensation of aniline and ethylcynoacetate, which was then reacted with p-chloro acetophenone, sulphur, diethyl amine to give 2-amino-4-(4- chlorophenyl)thiophene-3carboxamide. Later the compound was treated with twelve different substituted aryl aldehydes to yield twelve new Schiff bases (SBJ-Ia-l). The compounds were characterized by IR, 1H NMR and Mass spectral data and screened for CNS depressant activity.Keywords
Synthesis, Thiophenes, Schiff Bases, Spectral Analysis, CNS Depressant Activity.- Microwave Assisted Synthesis, Characterization and Antimicrobial Activity of Some Schiff Bases of 2-Amino (4-Chloro Phenyl) Thiazoles
Abstract Views :140 |
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Authors
Affiliations
1 Department of Pharmaceutical Chemistry, PES College of Pharmacy, Bangalore-50, Karnataka, IN
1 Department of Pharmaceutical Chemistry, PES College of Pharmacy, Bangalore-50, Karnataka, IN