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Authors
Affiliations
1 Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh-7861004, Assam, IN
2 Poona College of Pharmacy, Bharti Vidyapeeth University, Pune-411038, IN
Source
Asian Journal of Research in Chemistry, Vol 3, No 1 (2010), Pagination: 166-171
Abstract
A new series of coumarinaoacetamides (3a-h) have been synthesized by refluxing various chloroacetamides (2a-h) with 7-hydroxy-4-methyl chromen-2-one (1) in acetonitrile and anhydrous K2CO3. The chloroacetamides have been prepared from the chloroacetyl chloride with various substituted amines. The synthesized compounds have been characterized with the help of spectral and analytical data. The title compounds were screened for their antipsychotics activity in terms of their ability to inhibit apomorphine induced climbling behaviour in albino Swiss mice. All the compounds showed significant activity.
Keywords
Schizophrenia, Atypical Antipsychotics, Coumarinoacetamides.
