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Authors
Affiliations
1 Department of Chemistry, Yuvaraja's College, University of Mysore, Mysore - 570 005, IN
2 Adichunchanagiri Institute for Molecular Medicine, B.G. Nagara, Mandya-571 448, IN
3 Department of Chemistry, PES College of Engineering, Mandya-571401, IN
Source
Asian Journal of Research in Chemistry, Vol 10, No 2 (2017), Pagination: 127-130
Abstract
By incorporating a reduced amide bond φ [CH2NH] into α helical antibacterial peptide, we made an attempt to synthesize an antioxidant pseudo peptide. When the pKa value of reduced amide bond is between 6.5 to7.5, it is protonated depending on the pH. We investigated the antioxidant activity by hydroxyl radical scavenging assay and DPPH radical scavenging assay, the results showed that, the antioxidant activity of KL1 pseudo peptide (51%, 56%) were promising when compared to standard antioxidants like BHA(68%, 78%) and BHT (65%, 81%) respectively. The cyto-toxicity studies of the pseudo peptide showed that the peptide is non-toxic to cells.
Keywords
Pseudopeptide, Reduced Amide Bond Selectivity, Antioxidant, DPPH Radical, Superoxide Radical.
