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Authors
Affiliations
1 Department of Pharmaceutical Chemistry, Dr. D.Y.Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune-411 018, IN
Source
Asian Journal of Research in Chemistry, Vol 4, No 10 (2011), Pagination: 1600-1604
Abstract
Three simple, precise, accurate and reproducible spectrophotometric methods have been developed for the simultaneous estimation of Cefpodoxime proxetil (Cef) and Potassium clavulanate (Pot.clav.) in combined tablet dosage forms. The first method involves determination using the simultaneous equation method, the sampling wavelengths selected are 233.0 nm and 312.0 nm for Cef and Pot.clav. respectively. The second method involves determination using the multicomponent mode of the UV visible spectrophotometer, the sampling wavelengths selected are 233.0 nm and 312.0 nm for Cef and Pot.clav. respectively. The third method involves determination using the Area under curve, the sampling wavelength intervals selected are 235.0-231.0 nm and 314.0-310.0 nm for Cef and Pot.clav. respectively. All the methods were found linear in the concentration range of 1.5-50 μg/ml for both Cef and Pot.clav. The results of the analysis were validated statistically and recovery studies were carried out as per ICH guidelines.
Keywords
Cefpodoxime Proxetil, Potassium Clavulanate, Simultaneous Equation Method, Multicomponent Mode of Analysis, Area under Curve Method.
