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Palanisamy, Sivanandy
- Dipeptidylpeptidase-4 Inhibitory Activity of Pergularia Daemia (forsk) - An In-vitro Estimation
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Authors
Affiliations
1 Department of Pharmacology, Grace College of Pharmacy, Kodunthirapully, Palakkad, Kerala
2 Department of Pharmaceutical Chemistry, Grace College of Pharmacy, Kodunthirapully, Palakkad, Kerala
3 Department of Pharmacy Practice, KMCH College of Pharmacy, Coimbatore, Tamilnadu
1 Department of Pharmacology, Grace College of Pharmacy, Kodunthirapully, Palakkad, Kerala
2 Department of Pharmaceutical Chemistry, Grace College of Pharmacy, Kodunthirapully, Palakkad, Kerala
3 Department of Pharmacy Practice, KMCH College of Pharmacy, Coimbatore, Tamilnadu
Source
Asian Journal of Research in Chemistry, Vol 6, No 6 (2013), Pagination: 523-524Abstract
Dipeptidylpeptidase-4 is an enzyme involved in the inhibition of GLP-1 (Incretin), which is necessary for stimulation of insulin release. It is one of the enzyme targets for the treatment of type-2 diabetes mellitus. Ethanolic and aqueous extracts of Pergularia demia were investigated for activity using ellman method. Successive concentrations (50mg/ml, 100mg/ml, 200 mg/ml, 400 mg/ml, and 800 mg/ml) of ethanolic and aqueous extracts were prepared and investigated for their inhibitory activity towards dipeptidylpeptidase-4 as per Kojima et al., method. It was found that both extracts exhibited significant activity towards DPP-4 inhibition. Diprotein-A was used as standard and distilled water as control.Keywords
Diabetes Mellitus, Dipeptidylpeptidase-4, Pergularia Demia (forsk), Enzymes
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