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Authors
Affiliations
1 Appasaheb Birnale College of Pharmacy, Sangli-416416, Maharashtra, IN
Source
Asian Journal of Research in Chemistry, Vol 4, No 8 (2011), Pagination: 1262-1264
Abstract
A simple, accurate, sensitive, selective, precise and robust spectrophotometric method of analysis was suggested for determination of antiasthmatic drugs; Salmeterol xinafoate and Fluticasone propionate. The estimation of drugs was based on multicomponent mode of analysis, which involves the measurement of absorbance at two wavelengths 214 nm (λmax of SX) and 246 nm (λmax of FP). Phosphate buffer (pH 7.4): Ethanol (95%) (90:10) was used as solvent. The mean results of estimation for in capsule were 99.93±0.13 %&99.92±0.19 % for Salmeterol and Fluticasone respectively of the label claim. The proposed method was found to be linear in the range of 2 - 10 μg/ml with mean recovery in the range of 99.76% to 100.54%, for both the drugs. The developed new method was validated according to ICH guidelines and found to be accurate and precise. Thus the proposed method can be successfully applied for determination of Salmeterol xinafoate and Fluticasone propionate in routine analysis work.
Keywords
Salmeterol Xinafoate, Fluticasone Propionate, UV Spectroscopy, Multicomponent Mode, Capsule Dosage Form.
