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Authors
Affiliations
1 Department of Pharmaceutical Chemistry, H.S.K. College of Pharmacy, Bagalkot-580071, Karnataka, IN
2 Department of Pharmaceutical Chemistry, KLE’S College of Pharmacy, Vidyanagar, Hubli-580031, Karnataka, IN
Source
Asian Journal of Research in Chemistry, Vol 3, No 2 (2010), Pagination: 319-323
Abstract
Ortho, meta and para-nitroaniline was treated with methyl methacrylate in the presence of acetic acid to get methyl 2-methyl-3-(o, m and p-nitroanilino) propionates which was further treated with hydrazine hydrate (99%) in the presence of absolute ethanol to get 2-methyl-3-(o, m and p-nitroanilino) propanohydrazide. The above compound was then treated with carbon disulphide in the presence of alcoholic KOH and ethanol as a solvent to get 5-{1-methyl-2-(o, m andp-nitroanilino) ethyl}-1,3,4-oxadiazole-2-thiol.These compounds were further treated with mopholine/piperidine/diethyl amine/dimethyl amine/diphenyl amine to get title compounds. The newly synthesized compounds were characterized by spectral and elemental analysis and the compounds were tested for antimicrobial activity.
Keywords
Oxadiazole, Propionates, Propanohydrazide.
