Asian Journal of Research in Chemistry

V. Rele Rajan ¹, G. Rane Dattaprasad ¹

Affiliations
1 Department of Chemistry, D.G. Ruparel College, Mahim, Mumbai 400016, IN

Abstract

A simple precise, rapid accurate and sensitive non-aqueous potentiometric titration method was developed for quantitative determination of clopidogrel bisulphate from pharmaceutical dosage form. The titration was carried out using standardized 0.1 N perchloric acid. The proposed method was found to be precise with % RSD <1 (n = 6). The method showed strict linearity (r² > 0.9999) between 20 % to 100 % of 0.100 mg of drug substance weight. The percentage recovery of clopidogrel bisulphate in the optimized method was between 100.0 to 100.416 %. The method is also found to be rugged when checked by different analysts and using different lots of reagents and different makes of titrators.

Keywords

Clopidogrel Bisulphate, Perchloric Acid, Potassium Hydrogen Phthalate, Glacial Acetic Acid.

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V. Rele Rajan ¹, P. Tiwatane Prathamesh ¹

Affiliations
1 Department of Chemistry, D.G. Ruparel College, Mahim, Mumbai 400 016, IN

Abstract

A simple precise, rapid accurate and sensitive non-aqueous potentiometric titration method was developed for quantitative determination of alprazolam from pharmaceutical dosage form. The titration was carried out using standardized 0.1 N perchloric acid. The proposed method was found to be precise with % RSD <1 (n = 6). The method showed strict linearity (r² > 0.9999 ) between 20 % to 100 % of 0.100 mg of drug substance weight. The percentage recovery of alprazolam in the optimized method was between 100.0 to 100.416 %. The method is also found to be rugged when checked by different analysts and using different lots of reagents and different makes of titrators.

Keywords

Alprazolam, Perchloric Acid, Potassium Hydrogen Phthalate, Glacial Acetic Acid.

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V. Rele Rajan ¹

Affiliations
1 Central Research Laboratory, D.G. Ruparel College, Matunga, Mumbai 400016, IN

Abstract

A simple and precise third order derivative method have been developed and validated for the estimation of oxolamine citrate in bulk and its tablet formulation. Oxolamine citrate was estimated at 254.6 nm for the third order derivative UV-spectrophotometric method. Beer's law was obeyed in the concentration range of 1 to 14 μg / ml with coefficient of correlation value 0.9995 for third order derivative method. The method was tested and validated for various parameters according to ICH guidelines. The precision expressed as relative standard deviation, which was as 2.0487 % for the above method. The proposed method was successfully applied for the determination of oxolamine citrate in pharmaceutical formulation. Results of the analysis were validated statistically and were found to be satisfactory. The proposed methods are simple, easy to apply, low-cost and require relatively inexpensive instruments.

Keywords

Oxolamine Citrate, Third Order Derivative Spectroscopy.

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