Asian Journal of Research in Pharmaceutical Sciences

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Tylophora asthmatica L. Prevents Lipid Peroxidation in Acetaminophen Induced Hepato Toxicity in Rats


Affiliations
1 Department of Biotechnology, Bharathidasan University College (w), Orathanadu, Thanjavur, Tamilnadu, India
2 Department of Botany, Jamal Mohamed College, Trichy, Tamilnadu, India
3 Department of Microbiology, Meenakshi Chandrasekaran College of Arts and Science, Pattukkottai – 614 626, Thanjavur, Tamilnadu, India
     

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Methanolic extract of Tylophora asthmatica leaves were prepared and tested for its antilipidperoxidation effect against acetaminophen induced hepato toxicity in rats. Alteration in the levels of lipid peroxide, iron, ferritin, total cholesterol, total lipid and phospholipids were tested in both experiment and control group of rats. Acetaminophen [1gm/kg] has showed a significant increase [p<0.05] in experimental rats except the level of phospholipids, which showed a significant decrease [p<0.05] compared to control rats. Treatment with methanolic extract of Tylophora asthmatica leaves [200mg/kg] has brought back the altered levels of this parameter to the near normal levels in the dose dependent manner.

Keywords

Acetaminophen, Hepatoprotective, Tylophora asthmatica.
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  • Tylophora asthmatica L. Prevents Lipid Peroxidation in Acetaminophen Induced Hepato Toxicity in Rats

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Authors

R. Malathi
Department of Biotechnology, Bharathidasan University College (w), Orathanadu, Thanjavur, Tamilnadu, India
S. Ahamed John
Department of Botany, Jamal Mohamed College, Trichy, Tamilnadu, India
A. Cholarajan
Department of Microbiology, Meenakshi Chandrasekaran College of Arts and Science, Pattukkottai – 614 626, Thanjavur, Tamilnadu, India

Abstract


Methanolic extract of Tylophora asthmatica leaves were prepared and tested for its antilipidperoxidation effect against acetaminophen induced hepato toxicity in rats. Alteration in the levels of lipid peroxide, iron, ferritin, total cholesterol, total lipid and phospholipids were tested in both experiment and control group of rats. Acetaminophen [1gm/kg] has showed a significant increase [p<0.05] in experimental rats except the level of phospholipids, which showed a significant decrease [p<0.05] compared to control rats. Treatment with methanolic extract of Tylophora asthmatica leaves [200mg/kg] has brought back the altered levels of this parameter to the near normal levels in the dose dependent manner.

Keywords


Acetaminophen, Hepatoprotective, Tylophora asthmatica.