Asian Journal of Research in Pharmaceutical Sciences

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In-vivo Screening of Bougainvillea glabra Leaves for its Analgesic, Antipyretic and Anti-Inflammatory Activities


Affiliations
1 Department of Pharmacognosy, Anurag Pharmacy College, Ananthagiri (V), Kodad (M), Nalgonda (Dt), Andhra Pradesh, 508 206, India
2 Department of Pharmacology, Anurag Pharmacy College, Ananthagiri (V), Kodad (M), Nalgonda (Dt), Andhra Pradesh, 508 206, India
     

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Previous phytochemical analysis of methanolic extract of Bougainvillea glabra leaves (MEBG) has indicated the presence of steroids, flavonoids, glycosides and terpenoid types of compounds. Since these compounds are of pharmacological interest, coupled with the use of this plant in traditional medicine, prompted us to check Bougainvillea glabra leaves for possible analgesic anti inflammatory and anti-pyretic activities. The analgesic activity of MEBG was studied using tail immersion method in mice. While the efficacy of the MEBG (150 and 300mg/kg.p.o) was compared with pentazocaine 30 mg/kg. MEBG recorded 79.88 % inhibition with the highest dose and 81.21% with pentazocaine. The antipyretic activity of MEBG was studied in Brewer's yeast-induced pyrexia in rats. MEBG showed more significant activity. MEBG were also subjected to evaluate anti-inflammatory activity by carrageenan induced rat paw edema. Indomethacin (100mg/kg) was taken as standard drug. MEBG produced dose-dependent of oedema, which was comparable to Indomethacin and found to be 48.32% and 42.32 % inhibition in carrageenan induced rat paw edema model. Findings from the present study showed MEBG to possess central and peripheral analgesic activity, anti-inflammatory property similar to steroidal and non-steroidal agents as well as antipyretic effect.

Keywords

Bougainvillea glabra Leaves, Analgesic, Anti-Inflammatory and Anti-Pyretic Activity.
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  • Anonymous. The Wealth of India. Vol I, National Institute of Science Communications and Information Resources. Council of Scientific & Industrial Research. New Delhi.2000.p.68-72.

  • Heuer S, Richter S, Metzger JW, Wray V, Nimtz M, Strack D. Betacyanins and flavonoids from bracts of Bougainvillea glabra. Phytochem. 37; 1994: 761-767.

  • Sheeja E, Edwin E, Amal Raj A, Gupta VB, Rana AC. Pharmacognostical and preliminary phytochemical studies on Bougainvillea glabra Choisy. Planta Indica. 1; 2005: 33-36.

  • Giri SN, Biswas AK, Saha BP, Pal SP. Studies of the antiinflammatory action of Bougainvillea glabra leaves. Ind J Pharm Sci. 50; 1998: 42-49.

  • Otshudi AL, Foriers A, Vercruysse A, Van Zeebroeck A, Lauwers S. In vitro antimicrobial activity six medicinal plants traditionally used for treatment of dysentery and diarrhoea in Democratic Republic of Congo. Phytomedicine. 7; 2000: 167- 172.

  • Anonymous. Organization for economic Co-operation and development Guidance Document on Acute toxicity testing. Environment Directorate, OECD. Peris: 2001. P.1-24.

  • Hasan, S.M.R., M. Jamila, M.M. Majumder, R. Akter, M.M. Hossain, M.E.H. Mazumder, M.A. Alam, R.Jahangir, M.S. Rana and S. Rahman. Analgesic and antioxidant activity of the Hydromethanolic extract of Mikania scandens Willid Leaves. Am J Pharm Tox. 4; 2009: 1-7.

  • Ghule BV, Murugananthan G, yeole PG. Analgesic and Antipyretic effects of Capparis Zeylanica leaves. Fitoterapia. 78; 2007: 365-9.

  • Aiyelero, OM., Ibrahim ZG and Yaro AH. Analgesic and antiinflammatory properties of the methanol leaf extract of Ficus ingens (moraceae) in rodents. Nig Journ Pharm Sci. 8(2); 2009: 79-86.


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  • In-vivo Screening of Bougainvillea glabra Leaves for its Analgesic, Antipyretic and Anti-Inflammatory Activities

Abstract Views: 566  |  PDF Views: 2

Authors

A. Elumalai
Department of Pharmacognosy, Anurag Pharmacy College, Ananthagiri (V), Kodad (M), Nalgonda (Dt), Andhra Pradesh, 508 206, India
M. Chinna Eswaraiah
Department of Pharmacognosy, Anurag Pharmacy College, Ananthagiri (V), Kodad (M), Nalgonda (Dt), Andhra Pradesh, 508 206, India
Karisha Madhavi Lahari
Department of Pharmacology, Anurag Pharmacy College, Ananthagiri (V), Kodad (M), Nalgonda (Dt), Andhra Pradesh, 508 206, India
Hamed Ali Shaik
Department of Pharmacology, Anurag Pharmacy College, Ananthagiri (V), Kodad (M), Nalgonda (Dt), Andhra Pradesh, 508 206, India

Abstract


Previous phytochemical analysis of methanolic extract of Bougainvillea glabra leaves (MEBG) has indicated the presence of steroids, flavonoids, glycosides and terpenoid types of compounds. Since these compounds are of pharmacological interest, coupled with the use of this plant in traditional medicine, prompted us to check Bougainvillea glabra leaves for possible analgesic anti inflammatory and anti-pyretic activities. The analgesic activity of MEBG was studied using tail immersion method in mice. While the efficacy of the MEBG (150 and 300mg/kg.p.o) was compared with pentazocaine 30 mg/kg. MEBG recorded 79.88 % inhibition with the highest dose and 81.21% with pentazocaine. The antipyretic activity of MEBG was studied in Brewer's yeast-induced pyrexia in rats. MEBG showed more significant activity. MEBG were also subjected to evaluate anti-inflammatory activity by carrageenan induced rat paw edema. Indomethacin (100mg/kg) was taken as standard drug. MEBG produced dose-dependent of oedema, which was comparable to Indomethacin and found to be 48.32% and 42.32 % inhibition in carrageenan induced rat paw edema model. Findings from the present study showed MEBG to possess central and peripheral analgesic activity, anti-inflammatory property similar to steroidal and non-steroidal agents as well as antipyretic effect.

Keywords


Bougainvillea glabra Leaves, Analgesic, Anti-Inflammatory and Anti-Pyretic Activity.

References