Asian Journal of Research in Pharmaceutical Sciences

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A Comparative Evaluation of the Antioxidant Activity of Some Medicinal Plants Popularly Used in India


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1 Sri Indu Institute of Pharmacy, Sheiguda, R.R. Dist, 5010510, India
     

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The methanolic crude extracts of some commonly used medical plants were screened for their free radical scavenging properties using ascorbic acid as standard antioxidant. Free radical scavenging activity was evaluated using 1,1- diphenyl-2-picryl-hydrazyl (DPPH) free radical. The overall antioxidant activity of green tea (Camellia sinensis linn.) was the strongest, follows in descending order by black tea (Camellia sinesis linn.),Eugenia caryophyllus (spreng), Piper cubeba linn., Zea mays and Piper nigrum,. All the methanolic extracts exhibited antioxidant activity significantly. The IC50 of the methanolic extracts ranged between 6.7±0.1 and 144.1±2.2 and that of ascorbic acid was 8.9±0.1μg/ml. the study reveals that the consumption of these spices would exert several beneficial effects by virtue of their antioxidant activity.

Keywords

Antioxidant, DPPH, Ascorbic Acid, Free Radical Scavenging Activity.
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  • Aqil F, Ahmed I, Mehmood Z. Antioxidant and free radical scavenging properties of twelve traditionally used Indian medicinal plants. Turk J Biol 30: 177-183, 2006.

  • Devasagayam TPA, Tilak JC, Boloor KK et al. Review: Free radical and antioxidants in human health. Curr Stat Fut Pros JAPI 53:794-804, 2004.

  • Graham HN. Green tea composition, consumption, and polyphenol chemistry. Prev Med 21: 334-350, 1992.

  • Karthikeyan J, Rani P. Enzymatic and non-enzymatic antioxidantsin selected Piper species. Indian J Exp Biol 41: 135-140, 2003.

  • Gulcin I. The antioxidant and radical scavenging activities of blackpepper seeds. Int J Food Sci Nutr 56: 491-499, 2005.

  • Dorman HJ, Deans SG. Antimicrobial agents from plants: antibacterial activity of plant volatile oils. J Appl Microbiol 88:308-316, 2000.

  • Chaudhry NM, Tariq P. Bactericidal activity of black pepper, bay leaf, aniseed and coriander against oral isolates. Pak J Pharm Sci19: 214-218, 2006.

  • Park IK, Lee SG, Shin SC et al. Larvicidal activity of isobutylamides identified in Piper nigrum fruits against three mosquito species. J Agric Food Chem 50: 1866-1870, 2002.

  • Matsuda H, Kawaguchi Y, Yamazaki M et al. Melanogenesis stimulation in murine B16 melanoma cells by Piper nigrum leafextract and its lignan constituents. Biol Pharm Bull 27: 1611-1616, 2004.

  • Choi EM, Hwang JK. Effect of some medicinal plants on plasma antioxidant system and lipid levels in rats. Phytother Res 19: 382-386, 2005.

  • Nair S, Nagar R, Gupta R. Antioxidant phenolics and flavonoids incommon Indian foods. J Assoc Physicians (India) 46: 708-710,1998.

  • Zafar R, Mujeeb M. Retinoid and rutin in callus culture of Tephrosia purpurea pers. Indian. J Pharm Sci 3 (Suppl. 2): 58-61, 2002.

  • Braca A, Sortino C, Politi M et al. Anti-oxidant activity of flavonoids from Licanialicaniaeflora. J Ethnopharmacol 79: 379-381, 2002.

  • Bors W, Saran M, Elstner EF. Screening for plant anti-oxidants. In: Linskens HF, Jackson JF. eds. Modern Methods of Plant Analysis-Plant Toxin Analysis-New Series, Vol 13. Springer, Berlin; 1992: pp. 277-295.

  • Lee J, Koo N, Min DB. Reactive oxygen species, aging and antioxidative neutraceuticals. Comp Rev Food Sci Food Safety 3:21-33, 2004.


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  • A Comparative Evaluation of the Antioxidant Activity of Some Medicinal Plants Popularly Used in India

Abstract Views: 473  |  PDF Views: 2

Authors

Ch. Madhu
Sri Indu Institute of Pharmacy, Sheiguda, R.R. Dist, 5010510, India
J. Swapna
Sri Indu Institute of Pharmacy, Sheiguda, R.R. Dist, 5010510, India
K. Neelima
Sri Indu Institute of Pharmacy, Sheiguda, R.R. Dist, 5010510, India
Monic V. Shah
Sri Indu Institute of Pharmacy, Sheiguda, R.R. Dist, 5010510, India

Abstract


The methanolic crude extracts of some commonly used medical plants were screened for their free radical scavenging properties using ascorbic acid as standard antioxidant. Free radical scavenging activity was evaluated using 1,1- diphenyl-2-picryl-hydrazyl (DPPH) free radical. The overall antioxidant activity of green tea (Camellia sinensis linn.) was the strongest, follows in descending order by black tea (Camellia sinesis linn.),Eugenia caryophyllus (spreng), Piper cubeba linn., Zea mays and Piper nigrum,. All the methanolic extracts exhibited antioxidant activity significantly. The IC50 of the methanolic extracts ranged between 6.7±0.1 and 144.1±2.2 and that of ascorbic acid was 8.9±0.1μg/ml. the study reveals that the consumption of these spices would exert several beneficial effects by virtue of their antioxidant activity.

Keywords


Antioxidant, DPPH, Ascorbic Acid, Free Radical Scavenging Activity.

References