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Efficacy of Magnesium Sulphate in Attenuation of Succinylcholine Induced Fasciculations - A Dose Finding Study
Succinylcholine is still a drug of choice for general anaesthesia practice, rapid sequence intubation and in patients having predicted difficult airway. However, it is associated with undesirable effect like fasciculation with incidence being 94%. Magnesium competes with calcium at the neuromuscular junction and inhibits release of acetylcholine and has been shown to reduce incidence of fasciculations.
Fasciculations, Magnesium Sulphate, Succinylcholine.
- Sakuraba S, Serita R, Kosugi S, et al. Pretreatment with magnesium sulphate is associated with less succinylcholine-induced fasciculation and subsequent tracheal intubation-induced hemodynamic changes than precurarization with vecuronium during rapid sequence induction. Acta Anaesthesiol Belg 2007;57(3):253-257
- Mahendra Kumar, Nalin Talwar, Ritu Goyal, Usha Shukla, AK Sethi. Effect of magnesium sulfate with propofol induction of anesthesia on succinylcholine-induced fasciculations and myalgia. Journal of Anaesthesiology Clinical Pharmacology. 2012; 28(1):81-85
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