Open Access
Subscription Access
Efficacy of Magnesium Sulphate in Attenuation of Succinylcholine Induced Fasciculations - A Dose Finding Study
Succinylcholine is still a drug of choice for general anaesthesia practice, rapid sequence intubation and in patients having predicted difficult airway. However, it is associated with undesirable effect like fasciculation with incidence being 94%. Magnesium competes with calcium at the neuromuscular junction and inhibits release of acetylcholine and has been shown to reduce incidence of fasciculations.
Keywords
Fasciculations, Magnesium Sulphate, Succinylcholine.
User
Font Size
Information
- Sakuraba S, Serita R, Kosugi S, et al. Pretreatment with magnesium sulphate is associated with less succinylcholine-induced fasciculation and subsequent tracheal intubation-induced hemodynamic changes than precurarization with vecuronium during rapid sequence induction. Acta Anaesthesiol Belg 2007;57(3):253-257
- Mahendra Kumar, Nalin Talwar, Ritu Goyal, Usha Shukla, AK Sethi. Effect of magnesium sulfate with propofol induction of anesthesia on succinylcholine-induced fasciculations and myalgia. Journal of Anaesthesiology Clinical Pharmacology. 2012; 28(1):81-85
Abstract Views: 746
