Efficacy of Subhypnotic Dose of Midazolam for Intraoperative Nausea and Vomiting during Cesarean Section under Spinal Anaesthesia, a Prospective, Open Lable, Placebo Control Study

Nausea and vomiting during spinal anaesthesia for caeserian section are very common and unpleasant. They cause significant distress to the patient and also interfere with surgical procedure. Subhypnotic dose of midazolam is attributed to prevent these side effects during cesarean section under spinal anaesthesia. Aim of our study was to evaluate the efficacy of subhypnotic dose of midazolam in preventing intraoperative nausea and vomiting.

Methods: Prospective, open label, placebo-controlled study was carried out. Patients were allocated to two groups of 30 each. One group received midazolam 0.02mg/kg bolus after cord is clamped and 0.01mg/kg half hourly thereafter till surgery ends. Other group received NS as control. Intraoperative emetic episodes were noted.