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Maintaining the Telomere and its Implication in Cancer


Affiliations
1 Department of Molecular and Human Genetics, Centre for Genomics, Jiwaji University, Gwalior 474 011, India
 

Genomic instability has been proposed as one of the emerging hallmarks of cancer. However, molecular mechanisms which cause genomic or chromosomal instability still elude us in various cancers. One of the causes for this genomic instability is dysfunction of the telomere. Telomere dysfunction is associated with an increased risk for different cancers, which results, in principle, due to telomere shortening and loss of telomeric proteins which caps and guard telomeres to distinguish it from double-stranded breaks. In this review, we highlight existing understanding of telomeres, telomerase and their role in cancer progression.

Keywords

Cancer Progression, Epigenetics, Genomic Instability, Telomere Dysfunction, Telomerase.
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  • Maintaining the Telomere and its Implication in Cancer

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Authors

Satish S. Poojary
Department of Molecular and Human Genetics, Centre for Genomics, Jiwaji University, Gwalior 474 011, India
Pramod Kumar Tiwari
Department of Molecular and Human Genetics, Centre for Genomics, Jiwaji University, Gwalior 474 011, India

Abstract


Genomic instability has been proposed as one of the emerging hallmarks of cancer. However, molecular mechanisms which cause genomic or chromosomal instability still elude us in various cancers. One of the causes for this genomic instability is dysfunction of the telomere. Telomere dysfunction is associated with an increased risk for different cancers, which results, in principle, due to telomere shortening and loss of telomeric proteins which caps and guard telomeres to distinguish it from double-stranded breaks. In this review, we highlight existing understanding of telomeres, telomerase and their role in cancer progression.

Keywords


Cancer Progression, Epigenetics, Genomic Instability, Telomere Dysfunction, Telomerase.

References





DOI: https://doi.org/10.18520/cs%2Fv111%2Fi7%2F1166-1172