Current Science

The PDF file you selected should load here if your Web browser has a PDF reader plug-in installed (for example, a recent version of Adobe Acrobat Reader).

If you would like more information about how to print, save, and work with PDFs, Highwire Press provides a helpful Frequently Asked Questions about PDFs.

Alternatively, you can download the PDF file directly to your computer, from where it can be opened using a PDF reader. To download the PDF, click the Download link above.

Fullscreen Fullscreen Off


DNA damage agents constantly target the genome integrity causing lethal damages. Homologous DNA repair as universal error-free repair pathway constitutively acts to remove double strand breaks. Tumour suppressor genes are the major candidates and mediators of this pathway. In this context, we review the emerging role of BRCA1/PALB2/BRCA2/RAD51 complex and show how BRCA1 interact with different protein partners to be the first-line mediator of homologous DNA repair pathway at the site of DNA damage. A defect anywhere in this BRCA1/PALB2/BRCA2/RAD51 assembly halts formation and stabilization of nuclear foci of BRCA2 at DNA damage sites compromising HDR repair progression.

Keywords

Breast Cancer Susceptibity Gene 1, Hereditary Breast Cancer, Phosphorylation, Replication Protein A, Strand Invasion.
User
Notifications
Font Size