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A Method for Synthesis of Gold Nanoparticles Using 1-Amino-2-Naphthol-4-Sulphonic Acid as Reducing Agent


Affiliations
1 Animal Biochemistry Division, ICAR-National Dairy Research Institute, Karnal 132 001, India
2 Dairy Chemistry Division, ICAR-National Dairy Research Institute, Karnal 132 001, India
 

The present communication describes the synthesis of gold nanoparticles (AuNPs) using 1-amino-2- naphthol-4-sulphonic acid (ANSA) with enhanced stability. The method of preparation is similar to the conventional method using sodium citrate as reducing agent. Briefly, ANSA was quickly added to a boiled solution of hydrogen tetrachloroaurate under stirring, resulting in the synthesis of deep red-coloured AuNPs. The AuNPs prepared by ANSA (AuNPs-ANSA) exhibit twofold increase in stability towards sodium chloride over those prepared by sodium citrate. AuNPs-ANSA are 35.1 nm in size and particles has various shapes, viz. hexagonal, pentagonal, spherical, etc. AuNPs-ANSA can be functionalized with immunoglobulins and functionalized nanoparticles exhibit flow properties in lateral-flow assay.

Keywords

Gold Nanoparticles, Immunoglobulins, Lateral Flow Assay, Reducing Agent.
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  • A Method for Synthesis of Gold Nanoparticles Using 1-Amino-2-Naphthol-4-Sulphonic Acid as Reducing Agent

Abstract Views: 491  |  PDF Views: 147

Authors

Pooja Rawat
Animal Biochemistry Division, ICAR-National Dairy Research Institute, Karnal 132 001, India
Y. S. Rajput
Animal Biochemistry Division, ICAR-National Dairy Research Institute, Karnal 132 001, India
Mahesh K. Bharti
Animal Biochemistry Division, ICAR-National Dairy Research Institute, Karnal 132 001, India
Rajan Sharma
Dairy Chemistry Division, ICAR-National Dairy Research Institute, Karnal 132 001, India

Abstract


The present communication describes the synthesis of gold nanoparticles (AuNPs) using 1-amino-2- naphthol-4-sulphonic acid (ANSA) with enhanced stability. The method of preparation is similar to the conventional method using sodium citrate as reducing agent. Briefly, ANSA was quickly added to a boiled solution of hydrogen tetrachloroaurate under stirring, resulting in the synthesis of deep red-coloured AuNPs. The AuNPs prepared by ANSA (AuNPs-ANSA) exhibit twofold increase in stability towards sodium chloride over those prepared by sodium citrate. AuNPs-ANSA are 35.1 nm in size and particles has various shapes, viz. hexagonal, pentagonal, spherical, etc. AuNPs-ANSA can be functionalized with immunoglobulins and functionalized nanoparticles exhibit flow properties in lateral-flow assay.

Keywords


Gold Nanoparticles, Immunoglobulins, Lateral Flow Assay, Reducing Agent.



DOI: https://doi.org/10.18520/cs%2Fv110%2Fi12%2F2297-2300