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High Benzoic Acid Production in a Grape-Based Ayurvedic Medicinal Wine (ASAVA)


Affiliations
1 Inter University Centre for Bioscience and Department of Biotechnology and Microbiology, Kannur University, Thalassery Campus, Kannur 670 661, India
 

Fermentative production of benzoic acid is seldom reported and the present report serendipitously expressed it, though in small quantity (~30 mg/l). Lipoxygenases (LOXs) catalyse the stereo-specific insertion of molecular oxygen into arachidonic acid, leading to hydroxy derivatives as end products. Ser-endipitously found LOX inhibitor was benzoic acid, produced in Ayurvedic-fermented medicated wine, pippalyasava. The present study reports the signifi-cance of the polyphenol derivatives in a traditional Ayurvedic therapeutic preparation where LOX inhibi-tion might have a role, besides its importance in fermented benzoic acid production.

Keywords

Ayurvedic-Fermented Wine, Benzoic Acid, Inflammation, Lox Inhibitors, Polyphenol Metabolites.
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  • High Benzoic Acid Production in a Grape-Based Ayurvedic Medicinal Wine (ASAVA)

Abstract Views: 403  |  PDF Views: 153

Authors

Muringayil Joseph Tomy
Inter University Centre for Bioscience and Department of Biotechnology and Microbiology, Kannur University, Thalassery Campus, Kannur 670 661, India
Chelankara Suresh Sharanya
Inter University Centre for Bioscience and Department of Biotechnology and Microbiology, Kannur University, Thalassery Campus, Kannur 670 661, India
Abdulhameed Sabu
Inter University Centre for Bioscience and Department of Biotechnology and Microbiology, Kannur University, Thalassery Campus, Kannur 670 661, India
Madhathil Kovilakathu Haridas
Inter University Centre for Bioscience and Department of Biotechnology and Microbiology, Kannur University, Thalassery Campus, Kannur 670 661, India

Abstract


Fermentative production of benzoic acid is seldom reported and the present report serendipitously expressed it, though in small quantity (~30 mg/l). Lipoxygenases (LOXs) catalyse the stereo-specific insertion of molecular oxygen into arachidonic acid, leading to hydroxy derivatives as end products. Ser-endipitously found LOX inhibitor was benzoic acid, produced in Ayurvedic-fermented medicated wine, pippalyasava. The present study reports the signifi-cance of the polyphenol derivatives in a traditional Ayurvedic therapeutic preparation where LOX inhibi-tion might have a role, besides its importance in fermented benzoic acid production.

Keywords


Ayurvedic-Fermented Wine, Benzoic Acid, Inflammation, Lox Inhibitors, Polyphenol Metabolites.



DOI: https://doi.org/10.18520/cs%2Fv111%2Fi11%2F1836-1838