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If Systems Approach is the Way Forward, What can the Ayurvedic Theory of Tridosha Teach Us?


Affiliations
1 Department of NMR, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110 029, India
 

With a shift in focus from genes to cells, systems approach is not only revolutionizing cell biology, but is also providing impetus for clinical medicine to shift from a reductionistic to a holistic approach for efficient disease management. This inevitably brings into focus one of the longest unbroken healthcare systems in the world, namely ayurveda, the medical system indigenous to Indian subcontinent. A distinctive feature of ayurveda is its systems approach to health and disease. Through the theoretical framework of vata, pitta and kapha, ayurveda offers a new paradigm for understanding the human system as a networked functional entity wherein system properties are integral components. An open-minded dialogue between the cell-centric systems biology and organism-centric ayurveda can open new exciting vistas for research beneficial to both sciences, which could leave a major imprint on clinical practice.

Keywords

Ayurveda, Kapha, Pitta, Systems Approach, Tridosha, Vata.
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  • Naylor, S. and Chen, J. Y., Unraveling human complexity and disease with systems biology and personalized medicine. Per. Med., 2010, 7, 275–289.

  • Hanash, S., Schliekelman, M., Zhang, Q. and Taguchi, A., Integration of proteomics into systems biology of cancer. Wiley Interdiscip. Rev. Syst. Biol. Med., 2012, 4, 327–337.

  • West, G. B., The importance of quantitative systemic thinking in medicine. Lancet, 2012, 379, 1551–1559.

  • Zou, J., Zheng, M. W., Li, G. and Su, Z. G., Advanced systems biology methods in drug discovery and translational biomedicine. Biomed. Res. Intl., 2013, 2013, 1–8 (Article ID 742835).

  • Ayers, D. and Day, P. J., Systems medicine: The application of systems biology approaches for modern medical research and drug development. Mol. Biol. Intl., 2015, 2015, 1–8 (Article ID 698169).

  • Mukerjee, G. N., History of Indian Medicine, Chaukhamba Sanskrit Pratisthan, Delhi, 2006.

  • Bavadekar, S., Mimansa. J. Ayur. Integ. Med., 2011, 2, 37–41.

  • Anupam, A. and Dwivedi, R. R., Concept of satkaaryavada in darshana and its application in ayurveda. Ayurveda, 2013, 34, 143–146.

  • Jayasundar, R., Ayurveda: a distinctive approach to health and disease. Curr. Sci., 2010, 98, 908–914.

  • Hankey, A., Ayurvedic physiology and etiology: Ayurvedo Amritanaam. The doshas and their functioning in terms of contemporary biology and physical chemistry. J. Alt. Compl. Med., 2001, 7, 567–574.

  • Hankey, A., A test of the systems analysis underlying the scientific theory of ayurveda’s tridosha. J. Alt. Compl. Med., 2005, 11, 385–390.

  • Rioux, J., A complex, nonlinear dynamic systems perspective on ayurveda and ayurvedic research. J. Alt. Compl. Med., 2012, 18, 709–718.

  • Sharma, P. V. (Translator), Sutra Sthanam (volume 1), Susruta Samhita, Chaukhamba Visvabharati, Varanasi, 2004, chapter 21, verse 5, p. 225.

  • Srikantha Murthy, K. R. (Translator), Sutra Sthanam (volume 1), Ashtanga Samgraha of Vagbhata, Chaukambha Orientalia, Varanasi, 2005, chapter 19, verse 2, p. 349.

  • Srikantha Murthy, K. R. (Translator), Sutra Sthanam (volume 1), Ashtanga Samgraha of Vagbhata, Chaukambha Orientalia, Varanasi, 2005, chapter 1, verses 36–37, p. 12.

  • Sharma, R. K. and Dash, B. (Translators), Sutra Sthanam (volume 1), Caraka Samhita, Chaukhamba Sanskrit Series Office, Varanasi, 2008, chapter 1, verses 59–61, p. 43.

  • Swainson, C. P. and Cumming, A. D., Disturbances in water, electrolyte and acid-base balance. In Davidson’s Principles and Practice of Medicine (eds Haslett, C. et al.), Churchill Livingston, New York, USA, 1999, pp. 393–416.

  • Armstrong-Helouvry, B., Control of Machines with Friction, The Springer Series in Engineering and Computational Science, Springer, New York, USA, 1991.

  • Tsortos, A., Papadakis, G. and Gizeli, E., The intrinsic viscosity of linear DNA. Biopolymers, 2011, 95, 824–832.

  • Bouffanais, R. and Yue, D. K. P., Hydrodynamics of cell-cell mechanical signaling in the initial stages of aggregation. Phys. Rev., 2010, 81, 1–16 (Article ID 041920).

  • Slaninova, I., Sestak, S., Svoboda, A. and Farkas, V., Cell wall and cytoskeleton reorganize as the response to hyperosmotic shock in Saccharomyces cerevisiae. Arch. Microbiol., 2000, 173, 245–252.

  • Ochola L. B. et al., Specific receptor usage in Plasmodium falciparum cytoadherence is associated with disease outcome. PLoS One, 2011, 6, 1–9 (Article ID e14741).

  • Dupont, S., Beney, L., Ferriera, T. and Gervais, P., Nature of sterols affects plasma membrane behaviour and yeast survival during dehydration. Biochim. Biophys. Acta, 2011, 1808, 1520–1528.

  • Dinicola, S. et al., A systems biology approach to cancer: fractals, attractors and nonlinear dynamics. OMICS A J. Integr. Biol., 2011, 15, 93–104.

  • Rudikoff, D., The effect of dryness on the skin. Clinics Dermatol., 1998, 16, 99–107.

  • Petrone, D. et al., A double-blind, randomized, placebo-controlled study of cevimeline in Sjőgren’s syndrome patients with xerostomia and keratoconjunctivits sicca. Arthritis Rheumatol., 2002, 46, 748–754.

  • Bert-Couto, S. A. et al., Clinical diagnosis of hyposalivation in hospitalized patients. J. Appl. Oral. Sci., 2012, 20, 157–161.

  • Benitez-del-Castillo, J. M. and Lemp, M. A., Ocular Surface Disorders, JP Medical Publishers, London, 2013.

  • Ozturk, A. B., Ozturk, E. and Kasapoglu, E., Chronic cough due to mucosal dryness in primary Sjorgen’s syndrome: a case report. Tuberk. Toraks, 2014, 62, 243–244.

  • Nakajima, A. et al., Changes in synovial fluid biochemical markers following arthroscopic surgeries in patients with knee osteoarthritis. Rheumatol. Intl., 2013, 33, 209–214.

  • Jayasundar, R., Innovative applications of MR in the complementary and alternative medical system of ayurveda. Proc. Intl. Soc. Mag. Reson. Med., 2013, 21, 1523.

  • Verdier-Sevrain, S. and Bonte, F., Skin hydration: a review on its molecular mechanisms. J. Cosmet. Dermatol., 2007, 6, 75–82.

  • Srikantha Murthy, K. R. (Translator), Sutra Sthānam (volume 1), Ashtanga Samgraha of Vagbhata, Chaukambha Orientalia, Varanasi, 2005, chapter 20, verses 24–31, pp. 379–380.

  • Diestel, R., Graph Theory, Springer Verlag, Germany, 2010.

  • Chen, R. H. and Tsaih, M. L., Effect of temperature on the intrinsic viscosity and conformation of chitosans in dilute HCl solution. Intl. J. Biol. Macromol., 1998, 23, 135–141.

  • Seo, K., Lee, J. E., Lim, M. Y. and Ko, G., Effect of temperature, pH and NaCl on the inactivation kinetics of murine norovirus. J. Food Protocol, 2012, 75, 533–540.

  • Miri, A. K., Barthelat, F. and Mongeau, L., Effects of dehydration of the viscoelastic properties of vocal folds in large deformations. J. Voice, 2012, 26, 688–697.

  • Albert, R., Jeong, H. and Barabasi, A. L., Error and attack tolerance of complex networks. Nature, 2000, 406, 378–382.

  • Epstein, O., Thomas, H. C. and Sherlock, S., Primary biliary cirrhosis is a dry gland syndrome with features of chronic graftversushost disease. Lancet, 1980, 1, 1166–1168.

  • Finlayson, N. D. C., Hayes, P. C. and Simpson, K. J., Diseases of the liver and biliary system. In Davidson’s Principles and Practice of Medicine (eds Haslett, C. et al.), Churchill Livingston, New York, USA, 1999, pp. 689–728.

  • Citirik, M., Berker, N., Kacar, S. and Kekilli, M., Ocular findings in patients with autoimmune liver disease. Ocul. Immunol. Inflamm., 2012, 20, 438–442.

  • Sharma, R. K. and Dash, B. (Translators), Sutra Sthānam (volume 1), Caraka Samhita, Chaukhamba Sanskrit Series Office, Varanasi, 2008, chapter 17, verse 62, p. 322.

  • Srikantha Murthy, K. R. (Translator), Sutra Sthānam (volume 1), Ashtanga Hrdayam, Chaukambha Krishnadas Academy, Varanasi, 2005, chapter 1, verse 19, p. 12.

  • Jayasundar, R., Contrasting approaches to health and disease: ayurveda and biomedicine. In Medicine, State and Society: Indigenous Medicine and Medical Pluralism in Contemporary India (eds Sujata, V. and Abraham, L.), Orient BlackSwan, New Delhi, 2012, pp. 37–58.

  • Jayasundar, R., Quantum logic in ayurveda. In An Integrated Model of Health and Well-being. Bridging Indian and Western Knowledge (eds Morandi, A. and Nambi, A. N. N.), Springer, Heidelberg, Germany, 2013, pp. 115–139.

  • Jayasundar, R., Ayurvedic approach to functional foods. In Introduction to Functional Food Science (ed. Martirosyan, D. M.), Food Science Publisher, Texas, USA, 2013, pp. 454–479.

  • Chopra, A., Saluja, M. and Tillu, G., Ayurveda-modern medicine interface: a critical appraisal of studies of ayurvedic medicines to treat osteoarthritis and rheumatoid arthritis. J. Ayur. Integr. Med., 2010, 1, 190–198.

  • Daniel, E. F. et al., Double blind, randomized, controlled, pilot study comparing classic ayurvedic medicine, methotrexate, and their combination in rheumatoid arthritis. J. Clin. Rheumatol., 2011, 17, 185–192.


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  • If Systems Approach is the Way Forward, What can the Ayurvedic Theory of Tridosha Teach Us?

Abstract Views: 448  |  PDF Views: 136

Authors

Rama Jayasundar
Department of NMR, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110 029, India

Abstract


With a shift in focus from genes to cells, systems approach is not only revolutionizing cell biology, but is also providing impetus for clinical medicine to shift from a reductionistic to a holistic approach for efficient disease management. This inevitably brings into focus one of the longest unbroken healthcare systems in the world, namely ayurveda, the medical system indigenous to Indian subcontinent. A distinctive feature of ayurveda is its systems approach to health and disease. Through the theoretical framework of vata, pitta and kapha, ayurveda offers a new paradigm for understanding the human system as a networked functional entity wherein system properties are integral components. An open-minded dialogue between the cell-centric systems biology and organism-centric ayurveda can open new exciting vistas for research beneficial to both sciences, which could leave a major imprint on clinical practice.

Keywords


Ayurveda, Kapha, Pitta, Systems Approach, Tridosha, Vata.

References





DOI: https://doi.org/10.18520/cs%2Fv112%2Fi06%2F1127-1133