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Antioxidant and Alleviatory Effects of Hydroalcholic Extract of Cauliflower Leaves against Sodium Fluoride-Induced Cardiotoxicity in Wistar Male Rats


Affiliations
1 Department of Pharmacology, CMR College of Pharmacy, Hyderabad 501 401, India
2 Creative Education Society’s College of Pharmacy, Kurnool 518 218, India
3 Department of Biotechnology, Rayalaseema University, Kurnool 518 002, India
4 Department of Chemistry, Jawaharlal Nehru Technological University Anantapur, Ananthapuramu 515 002, India
5 Department of Pharmacognosy, CMR College of Pharmacy, Hyderabad 501 401, India
 

The objective of the present study was to explore the alleviatory effects of hydroalcoholic extract of Brassica oleracea var. botrytis (BOB) leaves against sodium fluoride (NaF)-induced cardiotoxicity. Animals served as group I (normal control), group II (toxic control) and groups III-V (treatment groups) received extract at doses of 100, 200 and 400 mg/kg body wt respectively. Group VI served as plant control and received extract at a dose of 400 mg/kg body wt. All groups, except groups I and VI, received NaF (100 ppm) through drinking water for 30 days. Results showed that administration of extract significantly minimized elevated serum levels of CK-MB and LDH, decreased cardiac lipid peroxidation, increased levels of reduced glutathione content and catalase enzyme in a dosedependent manner. The study revealed that BOB leaves show moderate antioxidant and alleviated sodium fluoride induced cardiotoxicity.

Keywords

Antioxidant Activity, Cardiac Markers, Cauliflower Leaves, Hydroalcoholic Extract, Sodium Fluoride.
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  • Antioxidant and Alleviatory Effects of Hydroalcholic Extract of Cauliflower Leaves against Sodium Fluoride-Induced Cardiotoxicity in Wistar Male Rats

Abstract Views: 382  |  PDF Views: 126

Authors

Raghavendra Mitta
Department of Pharmacology, CMR College of Pharmacy, Hyderabad 501 401, India
Ravindra Reddy Kandula
Creative Education Society’s College of Pharmacy, Kurnool 518 218, India
Raghuveer Yadav Pulala
Department of Biotechnology, Rayalaseema University, Kurnool 518 002, India
Narasimha Jayaveera Korlakunta
Department of Chemistry, Jawaharlal Nehru Technological University Anantapur, Ananthapuramu 515 002, India
Uma Maheswara Rao Vattikuti
Department of Pharmacognosy, CMR College of Pharmacy, Hyderabad 501 401, India

Abstract


The objective of the present study was to explore the alleviatory effects of hydroalcoholic extract of Brassica oleracea var. botrytis (BOB) leaves against sodium fluoride (NaF)-induced cardiotoxicity. Animals served as group I (normal control), group II (toxic control) and groups III-V (treatment groups) received extract at doses of 100, 200 and 400 mg/kg body wt respectively. Group VI served as plant control and received extract at a dose of 400 mg/kg body wt. All groups, except groups I and VI, received NaF (100 ppm) through drinking water for 30 days. Results showed that administration of extract significantly minimized elevated serum levels of CK-MB and LDH, decreased cardiac lipid peroxidation, increased levels of reduced glutathione content and catalase enzyme in a dosedependent manner. The study revealed that BOB leaves show moderate antioxidant and alleviated sodium fluoride induced cardiotoxicity.

Keywords


Antioxidant Activity, Cardiac Markers, Cauliflower Leaves, Hydroalcoholic Extract, Sodium Fluoride.

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DOI: https://doi.org/10.18520/cs%2Fv112%2Fi06%2F1183-1186