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Fluorescence Spectral Features of Blood Components of Pregnant Women


Affiliations
1 Laser Diagnosis of Cancers, College of Science, King Saud University, Riyadh 11451, Saudi Arabia
2 Department of Obstetrics and Gynecology, College of Medicine, King Khalid University Hospital, King Saud University, Riyadh 11451, Saudi Arabia
3 Department of Nuclear Physics, University of Madras, Chennai 600 025, India
4 Cancer Research Chair, College of Medicine, King Saud University, Riyadh 11451, Saudi Arabia
5 College of Medicine, King Saud University, Riyadh 11451, Saudi Arabia
 

During pregnancy, women experience various metabolic and hormonal changes that contribute to foetal development. These changes are investigated in the present study in terms of fluorescent biomolecules found in blood using synchronous fluorescence spectroscopy. Comparing a set of blood samples of 14 pregnant women against age-adjusted controls, it could be seen that the amino acid tryptophan is approximately twofold higher in blood plasma of pregnant women (P < 0.1), while the metabolite flavin adenine dinucleotide is approximately 25% lower. Further, the essential oxygen-carrying protein in the haemoglobin, porphyrin, is 80% higher in pregnant women. When these results were compared with the spectral features of blood components of patients with thalassaemia, it was found that erythrocytes had approximately 25% less haemolysis during the tenure of pregnancy.

Keywords

Fluorescent Biomolecules, Pregnancy, Red Blood Cells, Synchronous Fluorescence Spectra.
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  • Fluorescence Spectral Features of Blood Components of Pregnant Women

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Authors

Sandhanasamy Devanesan
Laser Diagnosis of Cancers, College of Science, King Saud University, Riyadh 11451, Saudi Arabia
Mashael AlShebly
Department of Obstetrics and Gynecology, College of Medicine, King Khalid University Hospital, King Saud University, Riyadh 11451, Saudi Arabia
Rudran Kalaivani
Department of Nuclear Physics, University of Madras, Chennai 600 025, India
Krishnan Sivaji
Department of Nuclear Physics, University of Madras, Chennai 600 025, India
Karim Farhat
Cancer Research Chair, College of Medicine, King Saud University, Riyadh 11451, Saudi Arabia
Mohamad Saleh AlSalhi
Laser Diagnosis of Cancers, College of Science, King Saud University, Riyadh 11451, Saudi Arabia
Mohamed AlAtawi
Department of Obstetrics and Gynecology, College of Medicine, King Khalid University Hospital, King Saud University, Riyadh 11451, Saudi Arabia
Danny Rabah
College of Medicine, King Saud University, Riyadh 11451, Saudi Arabia
Vadivel Masilamani
Laser Diagnosis of Cancers, College of Science, King Saud University, Riyadh 11451, Saudi Arabia

Abstract


During pregnancy, women experience various metabolic and hormonal changes that contribute to foetal development. These changes are investigated in the present study in terms of fluorescent biomolecules found in blood using synchronous fluorescence spectroscopy. Comparing a set of blood samples of 14 pregnant women against age-adjusted controls, it could be seen that the amino acid tryptophan is approximately twofold higher in blood plasma of pregnant women (P < 0.1), while the metabolite flavin adenine dinucleotide is approximately 25% lower. Further, the essential oxygen-carrying protein in the haemoglobin, porphyrin, is 80% higher in pregnant women. When these results were compared with the spectral features of blood components of patients with thalassaemia, it was found that erythrocytes had approximately 25% less haemolysis during the tenure of pregnancy.

Keywords


Fluorescent Biomolecules, Pregnancy, Red Blood Cells, Synchronous Fluorescence Spectra.

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DOI: https://doi.org/10.18520/cs%2Fv113%2Fi03%2F457-461