Current Science

Open Access Open Access  Restricted Access Subscription Access

2017 Nobel Prize in Chemistry–for CryoEM


Affiliations
1 TIFR-National Centre for Biological Sciences, GKVK Post, Bellary Road, Bengaluru-560 065, India
 

The 2017 Nobel Prize in Chemistry has been awarded to Jacques Dubochet, Joachim Frank and Richard Henderson for developing electron cryomicroscopy (cryoEM) for high-resolution determination of biological macromolecules in solution. It has long been realized that electron microscopy has the potential to reveal atomic details of macromolecules and this year's award is reflective on the various developments that have been made on specimen preparation, theoretical and computational approaches and detectors over the past four decades.
User
Notifications
Font Size

  • Crowther, R. A., Derosier, D. J. and Klug, A., Proc. R. Soc. London Series A – Math. Phys. Sci., 1970, 317(1530), 319–340.

  • Glaeser, R. M., J. Ulstrastruc. Res., 1971, 36(3–4), 466–482.

  • Unwin, P. N. T. and Henderson, R., J. Mol. Biol., 1975, 94(3), 425–432.

  • Henderson, R. and Unwin, P. N. T., Nature, 1975, 257(5521), 28–32.

  • Taylor, K. A. and Glaeser, R. M., Science, 1974, 186(4168), 1036–1037.

  • Taylor, K. A. and Glaeser, R. M., J. Ultrastruct. Res., 1976, 55(3), 448–456.

  • van Heel, M. and Frank, J., Ultramicroscopy, 1981, 6(2), 187–194.

  • Radermacher, M., Wagenknecht, T., Verschoor, A. and Frank, J., J. Microscopy – Oxford, 1987, 146, 113–136.

  • Frank, J., Shimkin, B. and Dowse, H., Ultramicroscopy, 1981, 6(4), 343–357.

  • van Heel, M. and Keegstra, W., Ultramicroscopy, 1981, 7(2), 113–130.

  • Vinothkumar, K. R., Zhu, J. P. and Hirst, J., Nature, 2014, 515(7525), 80–84.

  • Adrian, M., Dubochet, J., Lepault, J. and McDowall, A. W., Nature, 1984, 308(5954), 32–36.

  • Dubochet, J., Lepault, J., Freeman, R., Berriman, J. A. and Homo, J. C., J. Microscopy – Oxford, 1982, 128, 219–237.

  • Dubochet, J., Adrian, M., Chang, J. J., Homo, J. C., Lepault, J., McDowall, A. W. and Schultz, P., Q. Rev. Biophys., 1988, 21(2), 129–228.

  • Henderson, R., Baldwin, J. M., Ceska, T. A., Zemlin, F., Beckmann, E. and Downing, K. H., J. Mol. Biol., 1990, 213, 899–929.

  • Henderson, R., Q. Rev. Biophys., 1995, 28(2), 171–193.

  • Glaeser, R. M., J. Struct. Biol., 1999, 128, 3–14.

  • Rosenthal, P. B. and Henderson, R., J. Mol. Biol., 2003, 333(4), 721–745.

  • Faruqi, A. R. and McMullan, G., Q. Rev. Biophys., 2011, 44, 357–390.

  • Vinothkumar, K. R., Montogomery, M. G., Liu, S. and Walker, J., Proc. Natl. Acad. Sci., 2016, 113(45), 12709–12714.


Abstract Views: 684

PDF Views: 179




  • 2017 Nobel Prize in Chemistry–for CryoEM

Abstract Views: 684  |  PDF Views: 179

Authors

K. R. Vinothkumar
TIFR-National Centre for Biological Sciences, GKVK Post, Bellary Road, Bengaluru-560 065, India

Abstract


The 2017 Nobel Prize in Chemistry has been awarded to Jacques Dubochet, Joachim Frank and Richard Henderson for developing electron cryomicroscopy (cryoEM) for high-resolution determination of biological macromolecules in solution. It has long been realized that electron microscopy has the potential to reveal atomic details of macromolecules and this year's award is reflective on the various developments that have been made on specimen preparation, theoretical and computational approaches and detectors over the past four decades.

References





DOI: https://doi.org/10.18520/cs%2Fv113%2Fi08%2F1493-1496