Current Science

Open Access Open Access  Restricted Access Subscription Access

CRISPR-Cas:The Molecular Scissors for Genetic Disease Surgeries?


Affiliations
1 Department of Biotechnology, Friedrich-Loeffler-Institute, Mariensee, 31535 Neustadt, Germany
 

CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) is an emerging biomedical tool, which allows researchers to manipulate DNA sequence(s) for desired gene(s) function. Genetic disorders, namely sickle-cell anaemia and β-thalassemia, had corrected in the stem cells using CRISPR. Therefore, researchers are much optimistic that CRISPR can prevent and cure human diseases in the coming future. However, it is a debatable question that whether this tool is safe and effective for use in human.
User
Notifications
Font Size

  • Cong, L. et al., Science, 2013, 339, 819–823.

  • Dever, D. P. et al., Nature, 2016, 539, 384–389.

  • Liang, P. et al., Protein Cell, 2017, 8, 811.

  • Ledford, H., Nature, 2015, 526, 310–311.

  • Cyranoski, D., Nature, 2016, 539, 479.

  • National Guidelines for Stem Cell Research, Indian Council of Medical Research, Delhi, 2017; icmr.nic.in/guidelines/Guidelines_for_stem_cell_research_2017.pdf


Abstract Views: 423

PDF Views: 130




  • CRISPR-Cas:The Molecular Scissors for Genetic Disease Surgeries?

Abstract Views: 423  |  PDF Views: 130

Authors

Naresh L. Selokar
Department of Biotechnology, Friedrich-Loeffler-Institute, Mariensee, 31535 Neustadt, Germany

Abstract


CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) is an emerging biomedical tool, which allows researchers to manipulate DNA sequence(s) for desired gene(s) function. Genetic disorders, namely sickle-cell anaemia and β-thalassemia, had corrected in the stem cells using CRISPR. Therefore, researchers are much optimistic that CRISPR can prevent and cure human diseases in the coming future. However, it is a debatable question that whether this tool is safe and effective for use in human.

References





DOI: https://doi.org/10.18520/cs%2Fv115%2Fi3%2F383-385