Current Science

Open Access Open Access  Restricted Access Subscription Access

Inhibition Spectrum, Purification and Kinetic Study of Alpha-Amylase Inhibitor from Murraya koenigii Endophytic Actinobacterium (Streptomyces koyangensis Strain B025)


Affiliations
1 Department of Microbiology, College of Basic Sciences, Punjab Agricultural University, Ludhiana - 141 004, India
 

Diabetes mellitus type II, the chronic endocrine disorder, affects metabolism of carbohydrates, proteins, fats, electrolytes and water. This type of diabetes can only be controlled by maintaining low levels of blood glucose and through a healthy lifestyle1. The currently available medicines, viz. biguanides, sulphonylureas and thiazolidinediones, pose risks of secondary failure and prominent side-effects. Therefore, it is imperative to go for the alternative approach, a strong antidiabetic activity, without any spin-off results.
User
Notifications
Font Size

  • Midhet, F. M., Al-Mohaimeed, A. A. and Sharaf, F. K., Saudi Med. J., 2010, 31, 768–774.

  • Sinha, T. and Bandopadhyay, A., Int. J. Res. Pharm. Sci., 2012, 3, 360–368.

  • Saini, S. C. and Reddy, G. B. S., Am. J. Phytomed. Clin. Ther., 2015, 3, 363–368.

  • Kesari, N., Gupta, R. K. and Watal, G., J. Ethnopharmacol., 2004, 97, 247–251.

  • Tembhurne, S. V. and Sakarkar, D. M., J. Med. Plant Res., 2010, 4, 2418–2423.

  • Vinuthan, M. K., Girish, K. V., Ravindra, J. P., Jayaprakash and Narayana, K., Indian J. Physiol. Pharmacol., 2004, 48, 348–352.

  • Saini, P., Gangwar, M. and Kaur, A., Int. J. Biol. Chem. Sci., 2015, 2, 180–188.

  • Garvie, E. I., In Bergey’s Manual of Systematic Bacteriology (ed. Sneath, P. H. A.), Williams and Wilkins, 1986, pp. 1071–1075.

  • Kazeem, M. I., Adamson, J. O. and Ogunwande, I. A., BioMed. Res. Int., 2013; doi:10.1155/2013/527570.

  • Mehni, A. M. and Shahdadi, F., Int. J. Biosci., 2014, 4, 224–228.

  • Lehninger, A. L., Nelson, D. L. and Cox, M. M., Lehninger Principles of Biochemistry, W. H. Freeman & Co, 2008, 5th edn.

  • Tanaka, M., J. Int. Med. Res., 2012, 40, 1295–1303.

  • Rey, D. P., Ospina, L. F. and Aragon, D. M., Rev. Colomb. Cienc. Quím. Farm., 2015, 44, 72–89.

  • Meng, S., Cao, J., Fen, Q., Peng, J. and Hu, Y., J. Evid-Based Complementary Altern. Med., 2013; doi:10.1155/2013/801457.

  • Li, K. T., Zhou, J., Wei, S. J. and Cheng, X., Bioresour. Technol., 2012, 118, 580– 583.


Abstract Views: 416

PDF Views: 143




  • Inhibition Spectrum, Purification and Kinetic Study of Alpha-Amylase Inhibitor from Murraya koenigii Endophytic Actinobacterium (Streptomyces koyangensis Strain B025)

Abstract Views: 416  |  PDF Views: 143

Authors

P. Saini
Department of Microbiology, College of Basic Sciences, Punjab Agricultural University, Ludhiana - 141 004, India
M. Gangwar
Department of Microbiology, College of Basic Sciences, Punjab Agricultural University, Ludhiana - 141 004, India

Abstract


Diabetes mellitus type II, the chronic endocrine disorder, affects metabolism of carbohydrates, proteins, fats, electrolytes and water. This type of diabetes can only be controlled by maintaining low levels of blood glucose and through a healthy lifestyle1. The currently available medicines, viz. biguanides, sulphonylureas and thiazolidinediones, pose risks of secondary failure and prominent side-effects. Therefore, it is imperative to go for the alternative approach, a strong antidiabetic activity, without any spin-off results.

References





DOI: https://doi.org/10.18520/cs%2Fv115%2Fi3%2F393-395