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Thiamine an Unexplored, Ecologically Hormonizable, Nontoxic Catalyst for Benzoylation


Affiliations
1 University Institute of Pharmacy, Chhatrapati Shahu ji Maharaj University, Kalyanpur, Kanpur 208 024, India
 

Numerous catalysts have been evaluated to assist benzoylation since its origin (1883), each having their own pros and cons with respect to synthetic environment. However, the one (thiamine) we report here is superior as well as multidimensionally advantageous with reference to non-hygroscopic characteristic, stability at room temperature and reaction conditions, uninflammable, non-volatile, easy to handle, non-corrosive, environmentally harmonizable, biodegradable, recyclable and non-toxic. Our result denies the traditional concept of ‘Inorganic alkaline assistance’ for benzoylation. The percentage yield of benzoylated product obtained by thiamine assisted method was found to be comparable with traditional methods. Furthermore non-catalyst assisted benzoylation in neat water was also studied and the results coincide with traditional as well as thiamine-assisted method reported here with some limitations.

Keywords

Benzoylation, Catalyst, Clean Water, Thiamine.
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  • Thiamine an Unexplored, Ecologically Hormonizable, Nontoxic Catalyst for Benzoylation

Abstract Views: 352  |  PDF Views: 121

Authors

Deepak Chowrasia
University Institute of Pharmacy, Chhatrapati Shahu ji Maharaj University, Kalyanpur, Kanpur 208 024, India
Nisha Sharma
University Institute of Pharmacy, Chhatrapati Shahu ji Maharaj University, Kalyanpur, Kanpur 208 024, India

Abstract


Numerous catalysts have been evaluated to assist benzoylation since its origin (1883), each having their own pros and cons with respect to synthetic environment. However, the one (thiamine) we report here is superior as well as multidimensionally advantageous with reference to non-hygroscopic characteristic, stability at room temperature and reaction conditions, uninflammable, non-volatile, easy to handle, non-corrosive, environmentally harmonizable, biodegradable, recyclable and non-toxic. Our result denies the traditional concept of ‘Inorganic alkaline assistance’ for benzoylation. The percentage yield of benzoylated product obtained by thiamine assisted method was found to be comparable with traditional methods. Furthermore non-catalyst assisted benzoylation in neat water was also studied and the results coincide with traditional as well as thiamine-assisted method reported here with some limitations.

Keywords


Benzoylation, Catalyst, Clean Water, Thiamine.

References





DOI: https://doi.org/10.18520/cs%2Fv115%2Fi11%2F2130-2133