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Anti-Inflammatory Activity of Synthesized Diarylpentenedione Derivatives and their Drug Delivery with Silicon-Nanotube (7,7)


Affiliations
1 School of Electronics, Vignan's Foundation for Science, Technology and Research, Guntur - 522 213, India
2 Department of Biology, Education College, University of Al-Qadisiyah, Al Diwaniyah, Qadisiyyah, Iraq
3 Department of Management Sciences, COMSATS University, Islamabad Vehari Campus, Pakistan
4 Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah 67149-67346, Iraq
 

Earlier studies have confirmed that diarylpentenedione derivaties 1a and 1c have the highest and the lowest anti-inflammatory activity respectively. In this work, the interactions of diarylpentenedione derivatives 1a-1c with Si-nanotube (7,7) were studied and quantum molecular descriptors of the diarylpentenedione derivatives were calculated. Results showed that 1a-1c can interact with Si-nanotube (7,7) significantly and so their adsorptions were possible from an energetic viewpoint. Results also indicated that adsorption thermodynamic values of 1a on Si-nanotube (7,7) were higher than those of 1b and 1c. Therefore 1a has the highest chemical potential and electrophilicity index values. Thus the obtained theoretical and published experimental trends of anti-inflammatory activity of 1a-1c were similar.

Keywords

Adsorption Energy, Anti-Inflammatory and Chemical Potential, Diarylpentenedione Derivatives, Silicon Nanotube.
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  • Blagg, J., Structure-activity relationships for in vitro and in vivo toxicity. Annu. Rep. Med. Chem., 2006, 41, 353–368.

  • Razavi, R., Hosseini, S. M. A. and Ranjbar, M., Production of nanosized synthetic rutile from ilmenite concentrate by sonochemical HCl and H2SO4 leaching. Iran. J. Chem. Chem. Eng., 2014, 33, 29–36.

  • Razavi, R., Kardani, M. N., Ghanbari, A., Lariche, M. J. and Baghban, A., Utilization of LSSVM algorithm for estimating synthetic natural gas density. Petrol. Sci. Technol., 2018, 36, 807–812.

  • Parsaee, Z., Karachi, N. and Razavi, R., Ultrasound assisted fabrication of a novel optode base on a triazine based Schiff base immobilized on TEOS for copper detection. Ultrason. Sonochem., 2018, 47, 36-46.

  • Zahedifar, M., Razavi, R. and Sheibani, H., Reaction of (chloro carbonyl) phenyl ketene with 5-amino pyrazolones: Synthesis, characterization and theoretical studies of 7-hydroxy-6-phenyl-3(phenyldiazenyl) pyrazolo[1,5-a]pyrimidine-2,5(1H,4H)-dione derivatives. J. Mol. Struct., 2016, 1125, 730–735.

  • Karachi, N., Hosseini, M., Parsaee, Z. and Razavi, R., Novel high performance reduced graphene oxide based nanocatalyst decorated with Rh2O3/Rh-NPs for CO2 photoreduction. J. Photochem. Photobiol. A. Chem., 2018, 364, 344–354.

  • Seyedi, S. H., Saray, B. N. and Nobari, M. R. H., Using interpolation scaling functions based on Galerkin method for solving nonNewtonian fluid flow between two vertical flat plates. Appl. Math. Comput., 2015, 269, 488–496.

  • Moraga, R. J. and Rabiei Hosseinabad, E., A system dynamics approach in air pollution mitigation of metropolitan areas with sustainable development perspective: a case study of Mexico City. J. Appl. Environ. Biol. Sci., 2017, 7, 164–174.

  • Feili, H. R., Ahmadian, P. and Rabiei, E., Life cycle assessment of municipal solid waste systems to prioritize and compare their methods with multi-criteria decision making. OAJRE, 2014, 39, 1–12.

  • Azhiri, R. B., Sola, J. F., Tekiyeh, R. M., Javidpour, F. and Bideskan, A. S., Analyzing of joint strength, impact energy, and angular distortion of the ABS friction stir welded joints reinforced by nanosilica addition. Int. J. Adv. Manuf. Technol., 2018, 1, 1–14.

  • Azhiri, R. B., Tekiyeh, R. M., Zeynali, E., Ahmadnia, M. and Javidpour, F., Measurement and evaluation of joint properties in friction stir welding of ABS sheets reinforced by nanosilica addition. Measurement, 2018, 127, 198–204.

  • Ketabchy, M., Sample, D. J., Wynn-Thompson, T. and Yazdi, M. N., Thermal evaluation of urbanization using a hybrid approach. J. Environ. Manage., 2018, 226, 457–475.

  • Joshaghani, M., Ghasemi-Fare, O. and Ghavami, M., Experimental investigation on the effects of temperature on physical properties of sandy soils. IFCEE, 2018, 1, 675–685.

  • Khodabandeh, E., Rozati, S. A., Joshaghani, M., Akbari, O. A., Akbari, S. and Toghraie, D., Thermal performance improvement in water nanofluid/GNP–SDBS in novel design of double-layer microchannel heat sink with sinusoidal cavities and rectangular ribs. J. Therm. Anal. Calorim., 2018, 1, 1–13.

  • Jafarzadeh, F., Jahromi, H. F., Yoosefi, S., Sehizadeh, M., Joshaghani, M. and Alavi, M., Dynamic response of buried gas pipelines due to earthquake induced landslides by nonlinear numerical modeling. In The 15th World Conference on Earthquake Engineering, Beijing, China (15WCEE), 2012.

  • Pourmand, G., Safavi, M., Ahmadi, A., Houdeh, E., Noori, M., Mashhadi, R. and Pourmand, N., A silver lining for early diagnosis of prostate cancer. Urol. J., 2016, 13, 2845–2848.

  • Bakhshi, H., Khodabandeh, E., Akbari, O., Toghraie, D., Joshaghani, M. and Rahbari, A., Investigation of laminar fluid flow and heat transfer of nanofluid in trapezoidal microchannel with different aspect ratios. Int. J. Numer. Method H., 2018, 1, 1–13.

  • Pirbazari, A. E., Monazzam, P. and Kisomi, B. F., Desalin. Co/TiO2 nanoparticles: preparation, characterization and its application for photocatalytic degradation of methylene blue. Water Treat., 2017, 63, 283–292.

  • Ebrahimian Pirbazari, A., Fakhari Kisom, B. and Ghamangiz Khararoodi, M., Anionic surfactant-modified rice straw for removal of methylene blue from aqueous solution. Desalin. Water Treat., 2016, 57, 18202–18216.

  • Momtazan, M., Niyakan, M., Jaderi, T. and Hoseini Ahangari, S. A., The amount of scientific production of Ahvaz Jundishapur university of medical sciences on pubmed in 2000–2013. Res. J. Med. Sci., 2016, 10, 49–53.

  • Leopoldini, M., Marino, T., Russo, N. and Toscano, M., Antioxidant properties of phenolic compounds: H-atom versus electron transfer mechanism. J. Phys. Chem. A, 2004, 108, 4916–4922.

  • Nam, P. C., Nguyen, M. T. and Chandra, A. K., Assessment of the importance of changes in ground-state energies on the bond dissociation enthalpies of the O–H bonds in phenols and the S–H bonds in thiophenols. J. Phys. Chem. A, 2006, 110, 10904-10911.

  • Mohajeri, A. and Asemani, S. S., Theoretical investigation on antioxidant activity of vitamins and phenolic acids for designing a novel antioxidant. J. Mol. Struct: (Theochem), 2009, 930, 15–20.

  • Rimarcik, J., Lukes, V., Klein, E., Griesser, M. and Kelterer, A., Theoretical study of structure and electronic properties of cyanosubstituted pyrroles. Chem. Phys., 2008, 353, 177–184.

  • Brinck, T., Haeberline, M. and Jonsson, M., Theoretical study of X–H bond energetics (X = C, N, O, S) application to substituent effects, gas phase acidities, and redox potentials. J. Am. Chem. Soc., 1997, 119, 4239–4244.

  • Klein, E. and Lukes, V., Proton Affinities of para- and meta-substituted phenols in water. Chem. Phys., 2006, 330, 515–525.

  • Najafi, M., Zahedi, M. and Klein, E., DFT/B3LYP study of the solvent effect on the reaction enthalpies of homolytic and heterolytic OH bond cleavage in mono-substituted chromans. Comput. Theor. Chem., 2011, 978, 16–28.

  • Klein, E., Lukes, V. and Cibulkova, Z., Quantum-chemical study of C–H bond dissociation enthalpies of various small non-aromatic organic molecules. J. Mol. Struct.: (Theo-chem.), 2006, 758, 149–159.

  • Kumar, D., Kumar, N. M. and Sundaree, S., A facile synthesis of novel bis-(indolyl)-1,3,4-oxadiazoles as potent cytotoxic agents. Eur. J. Med. Chem., 2010, 45, 1244–1249.

  • Sadasivam, K. and Kumaresan, R., Theoretical investigation on the antioxidant behavior of chrysoeriol and hispidulin flavonoid compounds a DFT study. Comput. Theor. Chem., 2011, 963, 227-235.


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  • Anti-Inflammatory Activity of Synthesized Diarylpentenedione Derivatives and their Drug Delivery with Silicon-Nanotube (7,7)

Abstract Views: 459  |  PDF Views: 134

Authors

A. Surendar
School of Electronics, Vignan's Foundation for Science, Technology and Research, Guntur - 522 213, India
S. K. Sadulla
School of Electronics, Vignan's Foundation for Science, Technology and Research, Guntur - 522 213, India
Ali Noory Fajer
Department of Biology, Education College, University of Al-Qadisiyah, Al Diwaniyah, Qadisiyyah, Iraq
Mazhar Abbas
Department of Management Sciences, COMSATS University, Islamabad Vehari Campus, Pakistan
Meysam Najafi
Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah 67149-67346, Iraq

Abstract


Earlier studies have confirmed that diarylpentenedione derivaties 1a and 1c have the highest and the lowest anti-inflammatory activity respectively. In this work, the interactions of diarylpentenedione derivatives 1a-1c with Si-nanotube (7,7) were studied and quantum molecular descriptors of the diarylpentenedione derivatives were calculated. Results showed that 1a-1c can interact with Si-nanotube (7,7) significantly and so their adsorptions were possible from an energetic viewpoint. Results also indicated that adsorption thermodynamic values of 1a on Si-nanotube (7,7) were higher than those of 1b and 1c. Therefore 1a has the highest chemical potential and electrophilicity index values. Thus the obtained theoretical and published experimental trends of anti-inflammatory activity of 1a-1c were similar.

Keywords


Adsorption Energy, Anti-Inflammatory and Chemical Potential, Diarylpentenedione Derivatives, Silicon Nanotube.

References





DOI: https://doi.org/10.18520/cs%2Fv116%2Fi3%2F468-472