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Physico-Chemical, Photocatalytic and Cytotoxicity Evaluation of Annona muricata L. Fruit Extract Derived Zinc Oxide Nanoparticles in Comparison to the Commercial Chemical Version


Affiliations
1 Recombinant DNA Laboratory, Department of Biotechnology, School of Health Sciences, University of Calicut, Calicut University PO, Malappuram 673 635, India
2 School of Health Sciences, University of Calicut, Calicut University PO, Malappuram 673 635, India
 

The present study deployed a sol–gel method, employing an aqueous extract from the fruit of soursop, Annona muricata L. for the bio-assisted synthesis of zinc oxide nanoparticles (AmFZnNPs). Following the physico-chemical characterization by UV-Vis spectrometry, Fourier-transform infrared spectroscopy, X-ray diffraction, field-emission scanning electron microscopy and energy-dispersive X-ray spectroscopy, AmFZnNPs were evaluated for photocatalytic and bioactivities in comparison to commercially available chemically-derived zinc oxide nanoparticles (ZnONPs). AmFZnNPs exhibited good photocatalytic and potent antimicrobial activity in comparison to the weak and inefficient action of ZnONPs. Cytotoxicity of AmFZnNPs against colon carcinoma and leukaemic cells conspicuously contrasted with their non-lethality towards human lymphocytes/erythrocytes as well as onion ischolar_main tip cells whilst ZnONPs displayed high toxicity against all cell types tested except leukaemic cells. Besides the greater acceptability of production via eco-friendly green route, the superiority of AmFZnNPs over their chemically-derived counterparts is clearly demonstrated by our results.

Keywords

Annona muricata, Antimicrobial, Cytotoxicity, Nanoparticles, Photocatalytic, Zinc Oxide.
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  • Physico-Chemical, Photocatalytic and Cytotoxicity Evaluation of Annona muricata L. Fruit Extract Derived Zinc Oxide Nanoparticles in Comparison to the Commercial Chemical Version

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Authors

Ahlam Abdul Aziz
Recombinant DNA Laboratory, Department of Biotechnology, School of Health Sciences, University of Calicut, Calicut University PO, Malappuram 673 635, India
V. S. Shaniba
Recombinant DNA Laboratory, Department of Biotechnology, School of Health Sciences, University of Calicut, Calicut University PO, Malappuram 673 635, India
P. R. Jayasree
School of Health Sciences, University of Calicut, Calicut University PO, Malappuram 673 635, India
P. R. Manish Kumar
Recombinant DNA Laboratory, Department of Biotechnology, School of Health Sciences, University of Calicut, Calicut University PO, Malappuram 673 635, India

Abstract


The present study deployed a sol–gel method, employing an aqueous extract from the fruit of soursop, Annona muricata L. for the bio-assisted synthesis of zinc oxide nanoparticles (AmFZnNPs). Following the physico-chemical characterization by UV-Vis spectrometry, Fourier-transform infrared spectroscopy, X-ray diffraction, field-emission scanning electron microscopy and energy-dispersive X-ray spectroscopy, AmFZnNPs were evaluated for photocatalytic and bioactivities in comparison to commercially available chemically-derived zinc oxide nanoparticles (ZnONPs). AmFZnNPs exhibited good photocatalytic and potent antimicrobial activity in comparison to the weak and inefficient action of ZnONPs. Cytotoxicity of AmFZnNPs against colon carcinoma and leukaemic cells conspicuously contrasted with their non-lethality towards human lymphocytes/erythrocytes as well as onion ischolar_main tip cells whilst ZnONPs displayed high toxicity against all cell types tested except leukaemic cells. Besides the greater acceptability of production via eco-friendly green route, the superiority of AmFZnNPs over their chemically-derived counterparts is clearly demonstrated by our results.

Keywords


Annona muricata, Antimicrobial, Cytotoxicity, Nanoparticles, Photocatalytic, Zinc Oxide.

References





DOI: https://doi.org/10.18520/cs%2Fv117%2Fi9%2F1492-1504