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Green Protocol for the Synthesis of 1,8-Dioxo-Decahydroacridines by Hantzsch Condensation Using Citric Acid as Organocatalyst


Affiliations
1 Department of Chemistry, Rajaram College, Kolhapur 416 004, India
2 Department of Chemistry, P. D. V. P. College, Tasgaon 416 312, India
 

Herein we describe a clean and sustainable, one-pot, multi-component protocol for the synthesis of 1,8- dioxo-decahydroacridines by Hantzsch condensation of cyclic 1,3-dicarbonyl compound and NH4OAc with diverse aryl aldehydes using citric acid as an inexpensive green additive in ecological safe solvent. Utilization of cheaper and safer catalyst, cleaner reaction profile, straightforward work-up procedure and good to excellent yields of the desired product are the noteworthy aspects of this method.

Keywords

Acridines, Citric Acid, Organocatalysts, Green Protocol, Multi-Component Reactions.
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  • Green Protocol for the Synthesis of 1,8-Dioxo-Decahydroacridines by Hantzsch Condensation Using Citric Acid as Organocatalyst

Abstract Views: 387  |  PDF Views: 121

Authors

Monika Patil
Department of Chemistry, Rajaram College, Kolhapur 416 004, India
Shrikrishna Karhale
Department of Chemistry, Rajaram College, Kolhapur 416 004, India
Ananada Kudale
Department of Chemistry, Rajaram College, Kolhapur 416 004, India
Arjun Kumbhar
Department of Chemistry, P. D. V. P. College, Tasgaon 416 312, India
Sagar More
Department of Chemistry, P. D. V. P. College, Tasgaon 416 312, India
Vasant Helavi
Department of Chemistry, Rajaram College, Kolhapur 416 004, India

Abstract


Herein we describe a clean and sustainable, one-pot, multi-component protocol for the synthesis of 1,8- dioxo-decahydroacridines by Hantzsch condensation of cyclic 1,3-dicarbonyl compound and NH4OAc with diverse aryl aldehydes using citric acid as an inexpensive green additive in ecological safe solvent. Utilization of cheaper and safer catalyst, cleaner reaction profile, straightforward work-up procedure and good to excellent yields of the desired product are the noteworthy aspects of this method.

Keywords


Acridines, Citric Acid, Organocatalysts, Green Protocol, Multi-Component Reactions.

References





DOI: https://doi.org/10.18520/cs%2Fv116%2Fi6%2F936-942