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Biogenic Silver Nanoparticles Embedded Polyvinyl Alcohol Nanofibrous Scaffolds Avert Tumour and Bacterial Growth


Affiliations
1 Laboratory of Biopharmaceuticals and Nanomedicine, Division of Cancer Research, Regional Cancer Centre, Thiruvananthapuram 695 019, India
2 Chemical Sciences and Technology Division, Organic Chemistry Section, CSIR-National Institute for Interdisciplinary Science and Technology, Thiruvananthapuram 695 019, India
 

This communication describes a carefully designed strategy which blends biogenic silver nanoparticles with PVA scaffolds to fabricate SNP@PVA electrospun scaffolds with admirable physico-chemical properties. The hybrid scaffold demonstrated cyto-compatibility and hemo-compatibility with no adverse effects on the surrounding cells, as demonstrated by multiple assays. The growth of cancer cells was greatly prevented by SNP@PVA scaffolds, while allowing growth of normal cells. The outstanding antimicrobial features of the scaffold can be attributed to the presence of silver na-noparticles and proves the use of SNP@PVA for bio-medical applications.

Keywords

Cancer Cells, Electrospinning, Nanofibrous Scaffold, Polyvinyl Alcohol, Silver Nanoparticles.
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  • Preethi, G., et al., Biomedical applications of natural polymer based nanofibrous scaffolds. Int. J. Med. Nano Res., 2015, 2(010), 1–9.

  • Sahoo, R., Sahoo, S. and Nayak, P., Release behavior of anticancer drug paclitaxel from tamarind seed polysaccharide galactoxyloglucan. Eur. J. Sci. Res., 2010, 47(2), 197–206.

  • Rao, P., Ghosh, T. and Krishna, S., Extraction and purification of tamarind seed polysaccharide. J. Sci. Ind. Res., 1946, 4, 705.

  • Aravind, S. et al., Antitumor and immunopotentiating activity of polysaccharide PST001 isolated from the seed kernel of Tamarindus indica: an in vivo study in mice. Sci. World J., 2012, 2012, 1–14.

  • Joseph, M. M. et al., Exploration of biogenic nano-chemobiotics fabricated by silver nanoparticle and galactoxyloglucan with an efficient biodistribution in solid tumor investigated by SERS fingerprinting. ACS Appl. Mater. Interfaces, 2017, 9(23), 19578–19590.

  • Supaphol, P. and Chuangchote, S., On the electrospinning of poly (vinyl alcohol) nanofiber mats: a revisit. J. Appl. Polym. Sci., 2008, 108(2), 969–978.

  • Park, J.-C. et al., Electrospun poly(vinyl alcohol) nanofibres: effects of degree of hydrolysis and enhanced water stability. Polymer J., 2010, 42, 273.

  • Destaye, A. G., Lin, C.-K. and Lee, C.-K., Glutaraldehyde vapor cross-linked nanofibrous PVA mat with in situ formed silver nanoparticles. ACS Appl. Mater. Interfaces, 2013, 5(11), 4745–4752.

  • Ramya, A. N. et al., Emergence of gold‐mesoporous silica hybrid nanotheranostics: dox‐encoded, folate targeted chemotherapy with modulation of SERS fingerprinting for apoptosis toward tumor eradication. Small, 2017, 13(31), 159–172.

  • Ignatius, A. and Claes, L. E., In vitro biocompatibility of bioresorbable polymers: poly (L, DL-lactide) and poly (L-lactide-co-glycolide). Biomaterials, 1996, 17(8), 831–839.

  • Abdelgawad, A. M., Hudson, S. M. and Rojas, O. J., Anti-microbial wound dressing nanofiber mats from multicomponent (chitosan/silver-NPs/polyvinyl alcohol) systems. Carbohydr. Polym., 2014, 100, 166–178.

  • Joseph, M. M. et al., PST-gold nanoparticle as an effective anticancer agent with immunomodulatory properties. Colloids Surf. B, 2013, 104, 32–39.

  • Dasgupta, N. and Ramalingam, C., Silver nanoparticle anti-microbial activity explained by membrane rupture and reactive oxygen generation. Environ. Chem. Lett., 2016, 14(4), 477–485.

  • Devlin, J. P., Williamson, K. and Austin, G., Infrared spectrum of molten silver nitrate. J. Chem. Phys., 1966, 44(5), 2203–2204.

  • Zhou, C. and Yi, Z., Blood-compatibility of polyurethane/liquid crystal composite membranes. Biomaterials, 1999, 20(22), 2093–2099.

  • Koski, A., Yim, K. and Shivkumar, S., Effect of molecular weight on fibrous PVA produced by electrospinning. Mater. Lett., 2004, 58(3–4), 493–497.


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  • Biogenic Silver Nanoparticles Embedded Polyvinyl Alcohol Nanofibrous Scaffolds Avert Tumour and Bacterial Growth

Abstract Views: 320  |  PDF Views: 105

Authors

G. U. Preethi
Laboratory of Biopharmaceuticals and Nanomedicine, Division of Cancer Research, Regional Cancer Centre, Thiruvananthapuram 695 019, India
B. S. Unnikrishnan
Laboratory of Biopharmaceuticals and Nanomedicine, Division of Cancer Research, Regional Cancer Centre, Thiruvananthapuram 695 019, India
Manu M. Joseph
Chemical Sciences and Technology Division, Organic Chemistry Section, CSIR-National Institute for Interdisciplinary Science and Technology, Thiruvananthapuram 695 019, India
R. Shiji
Laboratory of Biopharmaceuticals and Nanomedicine, Division of Cancer Research, Regional Cancer Centre, Thiruvananthapuram 695 019, India
T. T. Sreelekha
Laboratory of Biopharmaceuticals and Nanomedicine, Division of Cancer Research, Regional Cancer Centre, Thiruvananthapuram 695 019, India

Abstract


This communication describes a carefully designed strategy which blends biogenic silver nanoparticles with PVA scaffolds to fabricate SNP@PVA electrospun scaffolds with admirable physico-chemical properties. The hybrid scaffold demonstrated cyto-compatibility and hemo-compatibility with no adverse effects on the surrounding cells, as demonstrated by multiple assays. The growth of cancer cells was greatly prevented by SNP@PVA scaffolds, while allowing growth of normal cells. The outstanding antimicrobial features of the scaffold can be attributed to the presence of silver na-noparticles and proves the use of SNP@PVA for bio-medical applications.

Keywords


Cancer Cells, Electrospinning, Nanofibrous Scaffold, Polyvinyl Alcohol, Silver Nanoparticles.

References





DOI: https://doi.org/10.18520/cs%2Fv116%2Fi10%2F1735-1741