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Hydroxychloroquine: A Relatively Obscure Antimalarial Takes Centre Stage in COVID-19


Affiliations
1 Department of Biochemistry, Indian Institute of Science, Bengaluru 560 012, India
2 Infectious Disease Biology, Institute of Life Sciences, Nalco Square, Bhubaneswar 751 023, India
 

Hydroxychloroquine (HCQ) is an old antimalarial known for its use to treat rheumatoid arthritis. Recently, it has been shown to be useful in COVID-19 treatment, although its efficacy is being debated and the data from large-scale clinical trials are yet to be available. Overall, it appears that HCQ-Azithromycin-Remdesevir may be a viable treatment option on a case to case basis. There is also a case to evaluate curcumin as an adjunct foodsupplement to prevent and treat COVID-19.
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  • Yeung, S., Pongtavornpinyo, W., Hastings, I. M., Mills, A. J. and White. N. J., Am. J. Trop. Med. Hyg., 2004, 71, 179–186.

  • Vincent, M. J. et al., Virology J., 2005, 2, 69; doi:10.1186/1743-422X-2-69.

  • Wang, M. et al., Cell Res., 2020, 30, 269–271.

  • Gao, J., Tian, Z. and Yang, X., Biosci. Trends, 2020, 14, 72–73; doi:10.5582/bst.2020.01047.

  • Gautret, P. et al., Int. J. Antimicrobial Agents, 2020,20, 105949; doi:10.1016/j.ijantimicag.2020.105949.

  • Barbosa, J. et al., N. Eng. J. Med., 4 April 2020 (submitted).

  • Savarino, A., Boelaert, J. R., Cassone, A., Majori, G. and Cauda, R., Lancet Infect. Dis., 2003, 3, 722–727; doi: 10.1016/s1473-3099(03)00806-5.

  • Schrezenmeier, E. and Dörner, T., Nat. Rev., 2020, 16, 155–166; doi:10.1038/s41584-020-0372-x.

  • Fitch, C. D., Trans. Am. Clin. Climatol. Assoc., 1998, 109, 97–106.

  • Loh, D., 24 March 2020; https://www.evolutamente.it/covid-19-ards-cell-free-hemoglobin-the-ascorbic-acid-connection/

  • Gonzales, J. N., Lucas, R. and Verin, A. D., Austin J. Vasc. Med., 2015, 2, pii; 1009.

  • Shaver, C. M. et al., Am. J. Physiol. Lung Cell Mol. Physiol., 2016, 310, L532–L541; doi:10.1152/ajplung.00155.2015.

  • University of Illinois-Chicago, Drug Information Group. Hydroxychloroquine, oral tablet. Healthline. Medically reviewed by Alex Brewer on 23 March 2020; https://www.healthline.com/health/hydroxychloroquine-oral-tablet

  • Cuhna, J. P., https://www.rxlist.com/aralen-side-effects-drug-center.htm

  • Vathsala, P. G. et al., PLoS ONE, 2012, 7, e29442; doi:10.1371/journal.pone.0029442.

  • Padmanaban, G. and Rangarajan, P. N., Trends Pharmacol. Sci., 2016, 37, 1–3.

  • Dende, C. et al., Sci. Rep., 2017, 7, 10062; doi:10.1038/s41598-017-10672-9.


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  • Hydroxychloroquine: A Relatively Obscure Antimalarial Takes Centre Stage in COVID-19

Abstract Views: 470  |  PDF Views: 158

Authors

Govindarajan Padmanaban
Department of Biochemistry, Indian Institute of Science, Bengaluru 560 012, India
Viswanathan Arun Nagaraj
Infectious Disease Biology, Institute of Life Sciences, Nalco Square, Bhubaneswar 751 023, India

Abstract


Hydroxychloroquine (HCQ) is an old antimalarial known for its use to treat rheumatoid arthritis. Recently, it has been shown to be useful in COVID-19 treatment, although its efficacy is being debated and the data from large-scale clinical trials are yet to be available. Overall, it appears that HCQ-Azithromycin-Remdesevir may be a viable treatment option on a case to case basis. There is also a case to evaluate curcumin as an adjunct foodsupplement to prevent and treat COVID-19.

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DOI: https://doi.org/10.18520/cs%2Fv118%2Fi10%2F1489-1491