Open Access
Subscription Access
Solvent Effects on Protonation Process of Clindamycin in Mixed Solvents
Clindamycin is used in the treatment of bacterial infections. The protonation constant of this drug was determined in mixed solvents of water and methanol as well as water and ethanol in the volume range 0–50 (% v/v) at 298.15 K and 0.1 M NaClO4 as the inert electrolyte. The results show that in both mixed solvents, pKa decreases when the volume fraction of alcohols increases. We considered the effect of the solvent on equilibrium constants using the electrostatic model of Born and the linear solvation energy relationship model developed by Kamlet and Taft. The results indicate that both hydrogen-bonding interactions and electrostatic interactions give rise to the observed changes. Using the derived equations, it is possible to determine pKa of clindamycin in the desired composition throughout the studied range.
Keywords
Antibiotic Drugs, Ethanol, Methanol, Protonation Constant, Solvent Effect.
User
Font Size
Information
Abstract Views: 262
PDF Views: 119